Lanostane triterpenoids from the fruiting bodies of Ganoderma amboinense

文献类型： 外文期刊

第一作者： Yang, Li

作者： Yang, Li;Dong, Guan-Hai;Ma, Qing-Yun;Xie, Qing-Yi;Guo, Jiao-Cen;Dai, Hao-Fu;Zhao, You-Xing;Yang, Li;Dong, Guan-Hai;Ma, Qing-Yun;Xie, Qing-Yi;Guo, Jiao-Cen;Dai, Hao-Fu;Zhao, You-Xing;Wu, You-Gen;Lu, Jia-Ju

作者机构：

关键词： Ganoderma amboinense . lanostane triterpenoid; alpha-glucosidase inhibitory activity; Anti-inflammatory activity

期刊名称：PHYTOCHEMISTRY （ 影响因子：3.8； 五年影响因子：4.0 ）

ISSN： 0031-9422

年卷期： 2024 年 218 卷

页码：

收录情况： SCI

摘要： Lanostane-type triterpenoids are the main characteristic constituents in Ganoderma mushrooms. Phytochemical analysis on the ethanol extract of the fruiting bodies of Ganoderma amboinense led to isolation and identification of twelve previously undescribed lanostane triterpenoids (1-12). Their chemical structures were determined by HR-ESI-MS, IR, and NMR spectroscopic analysis, NMR calculation, as well as X-ray crystallography. All isolates were evaluated for the alpha-glucosidase inhibitory and anti-inflammatory activities. Compounds 1, 5, 6, and 11 showed significant alpha-glucosidase inhibitory activity with IC50 values ranging from 33.5 mu M to 96.0 mu M. Moreover, compound 12 showed anti-inflammatory activity with IC50 value of 21.7 +/- 2.1 mu M.

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