Single-worm quantitative proteomics reveals aging heterogeneity in isogenic Caenorhabditis elegans

文献类型： 外文期刊

第一作者： Zhu, Tian-Yi

作者： Zhu, Tian-Yi;Liu, Dan-Dan;Zhang, Xiajun;Zhou, Lianqi;Yang, Bing;Zhu, Tian-Yi;Liu, Dan-Dan;Zhang, Xiajun;Zhou, Lianqi;Yang, Bing;Li, Shang-Tong;Zhou, Rong

作者机构：

关键词： aging; mass spectrometry; single worm proteomics

期刊名称：AGING CELL （ 影响因子：7.8； 五年影响因子：9.2 ）

ISSN： 1474-9718

年卷期： 2023 年

页码：

收录情况： SCI

摘要： The heterogeneity of aging has been investigated at cellular and organic levels in the mouse model and human, but the exploration of aging heterogeneity at whole-organism level is lacking. C. elegans is an ideal model organism for studying this question as they are self-fertilized and cultured in the same chamber. Despite the tremendous progress made in single-cell proteomic analysis, there is few single-worm proteomics studies about aging. Here, we apply single-worm quantitative mass spectrometry to quantify the heterogenous proteomic changes during aging across individuals, a total of 3524 proteins from 157 C. eleagns individuals were quantified. A reconstructed C. elegans aging trajectory and proteomic landscape of fast-aging individuals were used to analyze the heterogeneity of C. elegans aging. We characterized inter-individual proteomic variation during aging and revealed contributing factors that distinguish fast-aging individuals from their siblings.

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