文献类型： 外文期刊
第一作者： Wang, Xiwen
作者： Wang, Xiwen;Li, Song;Qu, Han;Wang, Kai;Xia, Zhiping;Li, Zhiping;Li, Qianxue;Wang, Xiwen;Hao, Liangyu;Shao, Ting;Li, Zhiping;Li, Qianxue
作者机构：
关键词： label-free; SERS
期刊名称：INFLUENZA AND OTHER RESPIRATORY VIRUSES （ 影响因子：4.4； 五年影响因子：4.1 ）
ISSN： 1750-2640
年卷期： 2023 年 17 卷 3 期
页码：
收录情况： SCI
摘要： The surface-enhanced Raman scattering (SERS) has recently drawn attention in the detection of respiratory viruses, but there have been few reports of the direct detection of viruses. In this study, a sandwich immunomagnetic bead SERS was established for the rapid diagnosis of the H5N1 influenza virus. The detection limit was estimated to be 5.0 x 10(-6) TCID50/ml. The method showed excellent specificity with no cross-reaction with H1N1, H5N6 or H9N2. The H5N1 influenza virus detection accuracy of the SERS method was 100% in chicken embryos. The results hold great promise for the utilization of SERS as an innovative approach in the diagnosis of influenza virus.
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