Genomic Insights into Post-Domestication Expansion and Selection of Body Size in Ponies

文献类型： 外文期刊

第一作者： Li, Xingzheng

作者： Li, Xingzheng;Wang, Binhu;Yuan, Pengxiang;Qu, Xiaolu;Wang, Zhen;Choudhury, Md. Panir;Yang, Xintong;Bao, Qi;He, Sang;Liu, Lei;Tang, Zhonglin;Yi, Guoqiang;Wang, Zihao;Zhu, Min;Teng, Shaohua;Yan, Jing;Cao, Shuwei;Wang, Haoyu;Zhan, Kai;Zhao, Pengju;Jiang, Jicai;Xiang, Hai;Fang, Lingzhao;Tang, Zhonglin;Yi, Guoqiang;Liao, Yuying;Yi, Guoqiang

作者机构：

关键词： body size; genome; pony; population genetics; regulatory elements

期刊名称：ADVANCED SCIENCE （ 影响因子：14.1； 五年影响因子：15.6 ）

ISSN：

年卷期： 2025 年 12 卷 16 期

页码：

收录情况： SCI

摘要： Horse domestication revolutionizes human civilization by transforming transportation, agriculture, and warfare patterns. Despite extensive studies on modern domestic horse origins, the intricate demographic history and genetic signatures underlying pony size remain unexplored. Here, a high-quality genome assembly of the Chinese Debao pony is presented, and 452 qualified individuals from 64 horse breeds worldwide are extensively analyzed. The authors' results reveal the conservation of ancient components in East Asian horses and close relationships between Asian horses and Western pony lineages. Genetic analyses suggest an Asian paternal origin for European pony breeds. These pony-sized horses share close genetic affinities, potentially attributed to their early expansion and adaptation to local environments. In addition, promising cis-regulatory elements influencing horse withers height by regulating genes such as RFLNA and FOXO1 are identified. Overall, this study provides insightful perspectives on the dispersal history and genetic determinants underlying body size in ponies, offering broader implications for horse population management and improvement.

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