High immunomodulatory and preventive effects against sarcoma 180 in mice fed with Ling Zhi or Reishi mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) mycelium

文献类型： 外文期刊

第一作者： Rubel, Rosalia

作者： Rubel, Rosalia;Dalla Santa, Herta Stutz;Soccol, Carlos Ricardo;Dalla Santa, Herta Stutz;Fernandes, Luiz Claudio;Cavalcante Lima Filho, Jose Hermenio;Figueiredo, Bonald Cavalcante;Di Bernardi, Raffaello;Moreno, Andrea N.;Leifa, Fan

作者机构：

关键词： Immune System: Chemical Coordination and Homeostasis;MC - Pharmacognosy: Pharmacology;MC - Tumor Biology

期刊名称：INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS （ 影响因子：1.921； 五年影响因子：1.879 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： This study evaluated the immunomodulatory and antitumor effects of a diet supplemented with Ganoderma lucidum (Ling Zhi or Reishi) medicinal mushroom mycelium obtained by solid-state fermentation. Over 14 weeks, animals from a test group were fed with 2 concentrations of G. lucidum mycelium, at 85% or 50%, labeled G85 and G50 diets, respectively. A control group received a regular diet. In the tenth week, half the animals from the test group and half the animals from the control group were inoculated with a suspension of Sarcoma 180 cells. Saline was injected in the remaining animals. In week 14, plasma levels of cytokines and the population of CD3(+), CD4(+), CD8(+), CD19(+), and CD16(+)/CD32(+) cells were evaluated. When compared to the control group, G. lucidum-supplemented diets altered the immune systems of the mice significantly (p < 0.05) the G50 diet proving more effective than the G85 diet. Mice inoculated with saline and fed with the G50 diet presented an increase in CD19(+) and CD16(+)/CD32(+) cell populations, along with an elevation in the tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma concentrations. Conversely, tumor-bearing mice fed with the G50 diet (labeled the G50-S group) presented an increase in CD3(+), CD4(+), and CD8(+) cells, but a decrease in CD19(+) and CD16(+)/CD32(+) cell populations. TNF-alpha and IFN-gamma concentrations were reduced in the G50-S group. The G50-S group presented a tumor weight 84% lower than that found in the control group. These results suggest that the immunomodulatory effect provoked by the consumption of G. lucidum mycelium possibly increased mice resistance against Sarcoma 180.

分类号： Q94

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