Synthesis and Insecticidal Activities of Novel Spin-Labeled Derivatives of Camptothecin
文献类型: 外文期刊
第一作者: Liu, Ying-Qian
作者: Liu, Ying-Qian;Dai, Wei;Tian, Jing;Zhou, Xing-Wen;Kou, Liang;Zhao, Yong-Long;Li, Wen-Qun;Li, Lin-Hai;Li, Hong-Yu;Yang, Liu;Feng, Gang
作者机构:
期刊名称:HETEROATOM CHEMISTRY ( 影响因子:1.366; 五年影响因子:1.162 )
ISSN:
年卷期:
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收录情况: SCI
摘要: Continuing our search for natural product based compounds for the control of Brontispa longissima larvae, eight spin-labeled camptothecin derivatives 7a-h and the intermediate 2 were first tested for their insecticidal activities against fifth-instar larvae of Brontispa longissima. Among all the tested compounds, especially compounds 7a and 2 showed promising insecticidal activities with the corrected mortality rates of 69.55% and 74.07% against fifth-instar larvae of B. longissima, respectively. The different insecticidal activity ranges of these compounds indicated that the variation of the structures of L-amino acids in these compounds markedly affected the activity profiles of this compound class, and some important SAR information has been revealed from it.
分类号: O626
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