Antinociceptive and anti-inflammatory activities of Phlomis umbrosa Turcz extract

文献类型： 外文期刊

第一作者： Shang, Xiaofei

作者： Shang, Xiaofei;Li, Maoxing;Shang, Xiaofei;Miao, Xiaolou;Pan, Hu;Yang, Yaoguang;Wang, Yu;Wang, Jinhui

作者机构：

关键词： xylene: 1330-20-7;acetic acid: 64-19-7;carrageenan: 9000-07-1;Evans blue: 314-13-6;iridoid glucosides;Phlomis umbrosa Turcz extract: antiinflammatory-drug;immunologic-drug;intraperitoneal administrati;Phlomis umbrosa aqueous extract: antiinflammatory-drug;immunologic-drug;intraperitoneal administra

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

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收录情况： SCI

摘要： Phlomis umbrosa Turcz has been used as the traditional medicine for thousands of years in China. In this paper, the acetic acid-induced writhing test, the hot plate test, the carrageenan-induced paw edema test, the xylene-induced ear swelling test, and the acetic acid-induced Evans blue leakage and leukocyte infiltration test were used to investigate the antinociceptive and anti-inflammatory activities of the aqueous extract of this plant (25, 50 and 100 mg/kg i.p.). Good dose-dependent effects were obtained in most of these tests, except in the hot plate test and the acetic acid-induced Evans blue leakage test. TLC and HPLC analyses showed iridoid glucosides were the main compositions of this extract. These findings suggested that the aqueous extract of P. umbrosa has significant antinociceptive and anti-inflammatory activities

分类号： S759.82

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