Decalactone derivatives from corynespora cassiicola, an endophytic fungus of the mangrove plant laguncularia racemosa

文献类型： 外文期刊

第一作者： Mandi, Attila

作者： Mandi, Attila;Kurtan, Tibor;Ebrahim, Weaam;Aly, Amal H.;Proksch, Peter;Debbab, Abdessamad;Ebrahim, Weaam;Totzke, Frank;Kubbutat, Michael H. G.;Wray, Victor;Lin, Wen-Han;Dai, Haofu

作者机构：

关键词： Conformation analysis;Drug discovery;Fungi;Lactones;Medicinal chemistry;Natural products;Structure elucidation

期刊名称：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY （ 影响因子：3.021； 五年影响因子：2.79 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Chemical investigation of the ethyl acetate extract of Corynespora cassiicola, isolated from leaf tissues of the Chinese mangrove medicinal plant Laguncularia racemosa, yielded four new secondary metabolites, including three decalactones, xestodecalactones D-F (1-3) as well as corynesidone C (4), in addition to four known compounds. The structures of the new compounds were determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. Absolute configurations of the optically active compounds 1-3 were determined by TDDFT ECD calculations of their solution conformers, proving that they belong to the (11S) series of xestodecalactones, opposite to the (11R) configuration of the known xestodecalactones A-C. All compounds were tested against a panel of human protein kinases. Among the isolated compounds, two inhibited several kinases such as IGF1-R and VEGF-R2 with IC _(50) values mostly in the low micromolar range. Three new xestodecalactones D-F (1-3) and a new corynesidone C were isolated from Corynespora cassiicola. The structures were determined by 1D and 2D NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of 1-3 were determined by TDDFT ECD calculations. All compounds were tested against a panel of human protein kinases.

分类号： O62

  • 相关文献

[1]Epigenetics in Schistosomes: What We know and What We Need know. Liu, Weiwei. 2016

[2]Insights into the Biosynthesis of 12-Membered Resorcylic Acid Lactones from Heterologous Production in Saccharomyces cerevisiae. Xu, Yuquan,Xu, Yuquan,Espinosa-Artiles, Patricia,Tang, Ying,Molnar, Istvan,Zhou, Tong,Zhan, Jixun,Tang, Ying,Molnar, Istvan.

[3]N, P Contribution and soil adaptability of four arbuscular mycorrhizal fungi. Wenke, Liu.

[4]Effects of Carbon Concentrations and Carbon to Nitrogen ratios on Sporulation of Two Biological Control Fungi as Determined by Different Culture Methods. Liu, Xingzhong,Gao, Li.

[5]Yield Improvement of the Anti-MRSA Antibiotics WAP-8294A by CRISPR/dCas9 Combined with Refactoring Self-Protection Genes in Lysobacter enzymogenes OH11. Yu, Lingjun,Liu, Fengquan,Yu, Lingjun,Su, Wei,Du, Liangcheng,Fey, Paul D.. 2018

[6]Control of damping-off of organic and conventional cucumber with extracts from a plant-associated bacterium rivals a seed treatment pesticide. Roberts, Daniel P.,Lakshman, Dilip K.,Maul, Jude E.,McKenna, Laurie F.,Buyer, Jeffrey S.,Fan, Bingquan.

[7]Genome Mining of the Biosynthetic Gene Cluster of the Polyene Macrolide Antibiotic Tetramycin and Characterization of a P450 Monooxygenase Involved in the Hydroxylation of the Tetramycin B Polyol Segment. Cao, Bo,Yao, Fen,Zheng, Xiaoqing,Cui, Dongbing,Shao, Yucheng,Deng, Zixin,You, Delin,Cao, Bo,Yao, Fen,Zheng, Xiaoqing,Cui, Dongbing,Shao, Yucheng,Deng, Zixin,You, Delin,Zhu, Changxiong.

[8]Functional studies of rat galactokinase. Chu, Xiusheng,Li, Nan,Liu, Xiaojun,Li, Ding,Chu, Xiusheng.

[9]Advances and prospects in biogenic substances against plant virus: A review. Zhao, Lei,Wu, Kuan,Chen, Wenbao,Chen, Yujia,Hao, Xingan,Wu, Yunfeng,Feng, Chaohong,Zhao, Lei,Wu, Kuan,Chen, Wenbao,Chen, Yujia,Hao, Xingan,Wu, Yunfeng,Zhao, Lei,Wu, Kuan,Chen, Wenbao,Chen, Yujia,Hao, Xingan,Wu, Yunfeng.

[10]Distribution of Baseline Sensitivities to Natural Product Physcion Among Isolates of Sphaerotheca fuliginea and Pseudoperonospora cubensis. Yang, X. J.,Ni, H.,Yang, X. J.,Yang, L. J.,Zeng, F. S.,Xiang, L. B.,Wang, S. N.,Yu, D. Z..

[11]Bioactive polyhydroxylated sterols from the marine sponge Haliclona crassiloba. Cheng, Zhong-Bin,Xiao, Han,Zhang, Ge,Yin, Sheng,Fan, Cheng-Qi,Lu, Ya-Nan. 2013

[12]Bandunamide, a novel cyclopeptide from the streptomyces Griseovariabilis bandungensis. Tian, XS,Xie, SD,Jiang, XB,Zhou, XM,Yang, LM,Xiao, DJ. 2003

[13]Strategies for structure elucidation of small molecules using gas chromatography-mass spectrometric data. Zhang, Liangxiao,Tang, Chunlan,Xiao, Hongbin,Zhang, Liangxiao,Cao, Dongsheng,Fan, Wei,Liang, Yizeng,Zeng, Yingxu,Tan, Binbin,Zeng, Maomao.

[14]Advances in Research of Polysaccharides in Cordyceps Species. Pan, Huijuan,Fan, Leifa,Lv, Guoying,Wu, Yongzhi,Zhong, Shi,Parmeswaran, Binod,Pandey, Ashok,Soccol, Carlos Ricardo. 2009

[15]New sesquiterpenoids from the edible mushroom Pleurotus cystidiosus and their inhibitory activity against alpha-glucosidase and PTP1B. Tao, Qiao-Qiao,Ma, Ke,Bao, Li,Wang, Kai,Han, Jun-Jie,Liu, Hong-Wei,Tao, Qiao-Qiao,Zhang, Jin-Xia,Huang, Chen-Yang.

[16]Polyketides from the plant endophytic fungus Cladosporium sp IFB3lp-2. Wuringege,Wei, Wei,Jiao, Rui-Hua,Yan, Tong,Zang, Le-Yun,Jiang, Rong,Tan, Ren-Xiang,Ge, Hui-Ming,Guo, Zhi-Kai. 2013

[17]Wortmannines A-C, three novel wortmannin derivatives with an unusual five-membered B ring from the endophytic fungus Talaromyces wortmannii LGT-4. Fu, Guang-Chao,Yang, Zhong-Duo,Shu, Zong-Mei,Xue, Hong-Yan,Wang, Yong-Gang,Yang, Zhong-Duo,Zhou, Shuang-Yan,Yao, Xiao-Jun,Li, Xin-Ming,Fang, Jian-Guo,Li, Xin-Ming,Fang, Jian-Guo,Yu, Hai-Tao.

[18]6,8-Di-C-methyl-flavonoids with neuroprotective activities from Rhododendron fortunei. Lai, Yongji,Zeng, Hong,Qian, Huiqin,Wu, Zhaodi,Luo, Zengwei,Xue, Yongbo,Yao, Guangmin,Zhang, Yonghui,Lai, Yongji,He, Meijun.

[19]Two new compounds, deacetylisowortmins A and B, isolated from an endophytic Fungus, Talaromyces wortmannii LGT-4. Fu, Guang-Chao,Yang, Zhong-Duo,Zhang, Fei,Yang, Zhong-Duo,Zhou, Shuang-Yan,Yao, Xiao-Jun,Yu, Hai-Tao.

[20]Mineral constituents of a prized edible mushroom (Tricholoma matsutake) and soils beneath the fruiting bodies from the production areas across China. Xiong Chuan,Li Xiao-lin,Zheng Lin-yong,Li Shu-hong,Li Qiang,Huang Wen-li,Xiong Chuan,Zheng Lin-yong,Liu Cheng-yi. 2016

作者其他论文 更多>>

微信小程序