Identification of human guanylate-binding protein 1 gene (hGBP1) as a direct transcriptional target gene of p53

文献类型： 外文期刊

第一作者： Zhu, Zixiang

作者： Zhu, Zixiang;Wei, Jianchao;Shi, Zixue;Yang, Yifan;Shao, Donghua;Li, Beibei;Ma, Zhiyong;Zhu, Zixiang;Wang, Xiaodu

作者机构：

关键词： Guanylate-binding proteins;Human guanylate-binding protein 1 gene;Interferon-inducible protein;P53

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Human guanylate-binding protein 1 (hGBP1) plays an important role in antitumor and antiviral immune responses. Here, we show that tumor suppressor p53 positively regulated hGBP1 transcription via binding to the p53 response element (p53RE) present in the hGBP1 promoter region. p53 activation by 5-fluorouracil significantly increased hGBP1 expression in wild-type p53 cells, but not in p53-null cells. Knockdown of p53 expression remarkably impaired hGBP1 expression induced by 5-fluorouracil, type I interferon treatment, or influenza A virus infection. Among three deductive p53REs present in the hGBP1 promoter region, two p53REs were found to be transactivated by p53.

分类号： Q5

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