The genome of the hydatid tapeworm Echinococcus granulosus

文献类型： 外文期刊

第一作者： Zheng, Huajun

作者： Zheng, Huajun;Zhang, Liang;Lu, Gang;Zhu, Yongqiang;Wang, Yuezhu;Huang, Yin;Kang, Hui;Chen, Jie;Wang, Lijun;Chen, Aojun;Yu, Shuting;Gao, Zhengchao;Jin, Lei;Gu, Wenyi;Wang, Zhiqin;Zhao, Guoping;Chen, Zhu;Wang, Shengyue;Zhang, Wenbao;Wen, Hao;Zhang, Liang;Zhao, Guoping;Zhou, Yan;Wang, Shengyue;Zhang, Zhuangzhi;Zhao, Li;Shi, Baoxin;Li, Jun;Jones, Malcolm K.;McManus, Donald P.;Brejova, Brona;Vinar, Tomas;Chen, Zhu;Chen, Zhu;Chen, Zhu;Wang, Shengyue

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期刊名称：NATURE GENETICS （ 影响因子：38.33； 五年影响因子：36.431 ）

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收录情况： SCI

摘要： Cystic echinococcosis (hydatid disease), caused by the tapeworm E. granulosus, is responsible for considerable human morbidity and mortality. This cosmopolitan disease is difficult to diagnose, treat and control. We present a draft genomic sequence for the worm comprising 151.6 Mb encoding 11,325 genes. Comparisons with the genome sequences from other taxa show that E. granulosus has acquired a spectrum of genes, including the EgAgB family, whose products are secreted by the parasite to interact and redirect host immune responses. We also find that genes in bile salt pathways may control the bidirectional development of E. granulosus, and sequence differences in the calcium channel subunit EgCa v β 1 may be associated with praziquantel sensitivity. Our study offers insights into host interaction, nutrient acquisition, strobilization, reproduction, immune evasion and maturation in the parasite and provides a platform to facilitate the development of new, effective treatments and interventions for echinococcosis control.

分类号： R394

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