NHE1 gene associated with avian leukosis virus subgroup J infection in chicken

文献类型： 外文期刊

第一作者： Chen, Biao

作者： Chen, Biao;Pan, Weiling;Zhang, Liangyu;Liu, Jing;Ouyang, Hongjia;Nie, Qinghua;Zhang, Xiquan;Chen, Biao;Pan, Weiling;Zhang, Liangyu;Liu, Jing;Ouyang, Hongjia;Nie, Qinghua;Zhang, Xiquan;Chen, Biao;Pan, Weiling;Zhang, Liangyu;Liu, Jing;Ouyang, Hongjia;Nie, Qinghua;Zhang, Xiquan

作者机构：

关键词： Chicken;NHE1 gene;ALV-J;SNP;Association analysis

期刊名称：MOLECULAR BIOLOGY REPORTS （ 影响因子：2.316； 五年影响因子：2.357 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： As a kind of binding protein, the type 1 Na+/H+ exchanger (NHE1) is a receptor for the highly pathogenic Avian leukosis viruses-J subgroup (ALV-J) in chicken. In order to investigate the potential effect of chicken NHE1 gene on leukosis, we compared its expression between ALV-J-affected and -unaffected chicken, screened variations across the whole gene, and then performed association analysis with ALV-J affected/unaffected trait in three un-related chicken populations. We found that the NHE1 gene expressed in four immune tissues including spleen, bursa fabricius, liver, and thymus, and its expression was significantly up-regulated in liver and thymus of ALV-J-affected chickens (with leukosis phenotype) compared to -unaffected ones (ALV-J-negative controls). Thirty-six single nucleotide polymorphisms (SNP) were identified in a 6,105 bp region of the chicken NHE1 gene, giving rise to every 170 bp per SNP. Two SNP of g.4405A > G and g.5886C > G were genotyped with PCR-RFLP method. Results showed that g.4405A > G was significantly associated (P < 0.05) with ALV-J infection in all of the three chicken populations, including White Recessive Rock (WRR), Dwarf Yellow (DY) and Shiki Yellow (SY), while g.5886C > G was significantly associated (P < 0.05) with ALV-J infection in SY. These results indicated that the NHE1 gene was related to ALV-J infection in chicken.

分类号： Q7

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