Saccharomyces boulardii prevention of the hepatic injury induced by Salmonella Enteritidis infection
文献类型: 外文期刊
第一作者: Wu, Daichao
作者: Wu, Daichao;Teng, Da;Wang, Xiumin;Wang, Jianhua;Wu, Daichao;Teng, Da;Wang, Xiumin;Dai, Changsong;Wang, Jianhua
作者机构:
关键词: Salmonella Enteritidis;translocation;colonisation;Saccharomyces boulardii;haematoxylin-eosin staining.
期刊名称:CANADIAN JOURNAL OF MICROBIOLOGY ( 影响因子:2.419; 五年影响因子:2.35 )
ISSN:
年卷期:
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收录情况: SCI
摘要: Salmonella enterica subsp. enterica serovar Enteritidis (Salmonella Enteritidis) is the predominant cause of serovar-associated food-borne outbreaks in many countries and causes significant clinical symptoms of liver injury, enteritis, and diarrheal diseases. Saccharomyces boulardii is used in clinical application for prophylaxis and the treatment of a variety of diseases caused by bacterial infection. We used a mouse model of Salmonella Enteritidis infection, which included pretreatment with S. boulardii, to reveal the protection mechanisms of S. boulardii against Salmonella Enteritidis infection, including the translocation of Salmonella Enteritidis to the liver 10 days after Salmonella Enteritidis challenge, and the colonisation of Salmonella Enteritidis and the formation of hepatic tissue lesions in mice after Salmonella Enteritidis challenge on the 10th day. Compared with Salmonella Enteritidis infection in mice, S. boulardii decreased Salmonella Enteritidis translocation to the liver by 96%, and 99% of Salmonella Enteritidis colonised the cecum on the 10th day. Saccharomyces boulardii also abated hepatic tissue injury caused by the infiltration of neutrophilic granulocytes, lymphocytes, and plasmocytes by decreasing the translocation of Salmonella to the liver. These findings demonstrated that S. boulardii is an effective agent in the prevention of the hepatic injury induced by Salmonella Enteritidis infection in a mouse model.
分类号: Q93
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