Type I interferon-mediated immune response against influenza A virus is attenuated in the absence of p53
文献类型: 外文期刊
第一作者: Zhu, Zixiang
作者: Zhu, Zixiang;Yang, Yifan;Wei, Jianchao;Shao, Donghua;Shi, Zixue;Li, Beibei;Liu, Ke;Qiu, Yafeng;Ma, Zhiyong;Zhu, Zixiang;Zheng, Haixue
作者机构:
关键词: Influenza A virus;Type I interferon;p53;Interferon-stimulated genes;Antiviral immune response
期刊名称:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ( 影响因子:3.575; 五年影响因子:3.381 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Influenza A virus (IAV) infection induces secretion of type I interferon (IFN) and activation of p53, which play essential roles in the host defense against tumor development and viral infection. In this study, we knocked down p53 expression by RNA interference. The expression levels of IFN-stimulated genes (ISGs) including IFN regulatory factor (IRF) 5, IRF9, ISG15, ISG20, guanylate-binding protein 1, retinoic acid-inducible gene-I and 2'-5'-oligoadenylate synthetase 1 were significantly attenuated in response to IAV infection and IFN-alpha stimulation in p53-knockdown cells. This attenuated expression of ISGs was associated with enhanced replication of IAV. Pretreatment of p53-knockdown cells with IFN-alpha failed to inhibit IAV replication, indicating impaired antiviral activity. These findings indicate that p53 plays an essential role in the enhancement of the type I IFN-mediated immune response against IAV infection. (C) 2014 Elsevier Inc. All rights reserved.
分类号: Q5
- 相关文献
作者其他论文 更多>>
-
An Overview of Zika Virus and Zika Virus Induced Neuropathies
作者:Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Wahaab, Abdul;Tran Nguyen Minh, Hieu;Rasgon, Jason L.;Mustafa, Bahar E.;Mustafa, Bahar E.;Tawaab, Abdul;Hameed, Muddassar;Hameed, Muddassar;Hameed, Muddassar;Batool, Hira;Shoaib, Anam;Wei, Jianchao
关键词:neurotropic flaviviruses; zika virus; neuropathies; transmission; neuropathogenesis; prevention; vaccines; treatment; antivirals; mosquito/vector control; oncolytic; animal and cell models
-
The wheat NLR pair RXL/Pm5e confers resistance to powdery mildew
作者:Guo, Guanghao;Hou, Yikun;Zhang, Huaizhi;Lu, Ping;Li, Miaomiao;Dong, Lingli;Xie, Jingzhong;Zhu, Keyu;Li, Beibei;Dong, Lei;Yang, Yijun;Qiu, Dan;Wang, Gaojie;Zhao, Yusheng;Chen, Yuhang;Liu, Zhiyong;Guo, Guanghao;Ahn, Hee-Kyung;Zhao, He;Jones, Jonathan D. G.;Bai, Kaihong;Hou, Yikun;Li, Beibei;Dong, Lei;Liu, Zhiyong;Gong, Zhen;Han, Guan-Zhu;Wu, Qiuhong;Chen, Yongxing;Li, Wenling;Li, Hongjie;Zhang, Panpan;Yuan, Chengguo;Shi, Wenqi;Xue, Minfeng;Yang, Lijun;Yu, Dazao;Hu, Tiezhu;Liu, Zhiyong;Ahn, Hee-Kyung
关键词:wheat; powdery mildew; NLR pair; hetero-complexes; resistance mechanism
-
Foot-and-mouth disease virus-like particle vaccine incorporating dominant T and B cell epitopes: enhanced immune response in piglets with CD154 molecules
作者:Li, Yuwan;Zeng, Weijun;Niu, Xinni;Yuan, Zhongmao;Li, Shurou;Lin, Jinru;Xie, Kaiyuan;Yi, Lin;Ding, Hongxing;Zhao, Mingqiu;Fan, Shuangqi;Chen, Jinding;Zhu, Zixiang
关键词:foot-and-mouth disease virus (FMDV); virus-like particle vaccine (VLP); CD154; T and B cell epitopes; ADDomer
-
Development of a Noninfectious Japanese Encephalitis Virus Replicon for Antiviral Drug Screening and Gene Function Studies
作者:Yang, Yang;Zheng, Jiayang;Lin, Yafang;Zhang, Hailong;Zhang, Junjie;Li, Zongjie;Liu, Ke;Li, Beibei;Shao, Donghua;Qiu, Yafeng;Ma, Zhiyong;Wei, Jianchao;Zhang, Yan;Zhao, Qianming
关键词:Japanese encephalitis virus; replicon; green fluorescent protein; antiviral drug screening; RNA replication
-
Sheep serve as amplifying hosts of Japanese encephalitis virus, increasing the risk of human infection
作者:Zhang, Hailong;Li, Dan;Zheng, Jiayang;Qiu, Yafeng;Liu, Ke;Li, Zongjie;Li, Beibei;Shao, Donghua;Ma, Zhiyong;Wei, Jianchao;Zhang, Hailong;Liu, Juxiang;Bao, Jingyue;Wang, Zhiliang
关键词:
-
Partial protective efficacy of the current licensed Japanese encephalitis live vaccine against the emerging genotype I Japanese encephalitis virus isolated from sheep
作者:Zhang, Hailong;Liu, Juxiang;Zhang, Yan;Li, Dan;Zheng, Jiayang;Zhang, Junjie;Li, Zongjie;Liu, Ke;Li, Beibei;Shao, Donghua;Qiu, Yafeng;Ma, Zhiyong;Wei, Jianchao
关键词:Japanese encephalitis virus; sheep; SA14-14-2 vaccine; neutralizing antibodies; protective efficacy
-
Flexible sensor based on molecular imprinting for simultaneous in situ detection of indole-3-acetic acid and salicylic acid in plants
作者:Liu, Ke;Chen, Liping;Zhao, Chunjiang;Liu, Ke;Hou, Peichen;Pan, Dayu;Zhou, Yanan;Luo, Bin;Chen, Liping;Zhao, Chunjiang;Li, Aixue
关键词:Molecularly imprinted polymer; In situ; MXene; Laser-induced graphene; Flexible sensor; Electrochemical biosensor