Enantioselective developmental toxicity and immunotoxicity of pyraclofos toward zebrafish (Danio rerio)

文献类型： 外文期刊

第一作者： Zhuang, Shulin

作者： Zhuang, Shulin;Zhang, Zhisheng;Zhang, Wenjing;Bao, Lingling;Zhuang, Shulin;Zhang, Wenjing;Bao, Lingling;Xu, Chao;Zhang, Hu

作者机构：

关键词： Pyraclofos;Aquatic toxicity;Enantioselectivity;Zebrafish;Modeling

期刊名称：AQUATIC TOXICOLOGY （ 影响因子：4.964； 五年影响因子：5.071 ）

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收录情况： SCI

摘要： Pyraclofos, a relatively new organophosphorus pesticide, has shown potential ecotoxicities, however, its aquatic toxicity, especially enantioselective aquatic toxicity, remains largely unknown. Using zebrafish (Danio redo) as a preeminent vertebrate aquatic model, the enantioselective differences in the developmental toxicity and immunotoxicity of pyraclofos were evaluated. Following 96-h exposure, pyraclofos enantiomers exhibited acute toxicity and showed lethal concentration 50 of 2.23 and 3.99 mg/L for (R)-Pyraclofos and (S)-Pyraclofos, respectively. Exposure to pyraclofos caused time- and concentration-dependent malformations such as pericardial edema, yolk sac edema, crooked bodies and hatching during the embryonic development, with markedly higher percentages of malformation at higher concentrations. The concentration-dependent immunotoxicity to zebrafish embryo exposed to low level pyraclofos was induced with significant up-regulation of mRNA levels of immune-related interleukin-1 beta (IL-1 beta) gene. (R)-Pyraclofos was consistently more toxic than (S)-Pyraclofos for the acute toxicity, developmental toxicity and immunotoxicity to zebrafish. Molecular dynamics simulations revealed that at the atomic level, (R)-Pyraclofos binds more potently to IL-1 beta protein than (S)-Pyraclofos. This enantioselective binding is mainly contributed by the distinct binding mode of pyraclofos enantiomers and their electrostatic interactions with IL-1 beta, which potentially affects IL-1 beta-dependent proinflammatory signal transduction. Our in vitro and in silica studies provided a better insight into the molecular basis for aquatic toxicity and thus improved the risk assessment for pyraclofos and other chiral organophosphorus pesticides. (C) 2014 Elsevier B.V. All rights reserved.

分类号： Q17

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