A New Cytotoxic Cytochalasin from the Endophytic Fungus Trichoderrna harzianum

文献类型： 外文期刊

第一作者： Chen, Huiqin

作者： Chen, Huiqin;Daletos, Georgios;Proksch, Peter;Okoye, Festus;Lai, Daowan;Dai, Haofu

作者机构：

关键词： Trichoderma harzianum;Endophytic fungus;Cytochalasin;Cytotoxicity

期刊名称：NATURAL PRODUCT COMMUNICATIONS （ 影响因子：0.986； 五年影响因子：1.068 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： The new natural product 4-hydroxy-deacety1-18-deoxycytochalasin H (1), together with the known deacety1-18-deoxycytochalasin H (2) and 18-deoxycytochalasin H (3) were obtained from the endophytic fungus Trichoderma harzianzim isolated from leaves of Cola nitida. The structure of the new compound was unambiguously determined by ID and 2D NNW. spectroscopy, and by HRESIMS measurements, as well as by comparison with the literature. Compounds 1-3 showed potent cytotoxic activity against the murine lymphoma (L5178Y) cell line and against human ovarian cancer (A2780 sens and A2780 CisR) cell lines (IC50 0.19-6.97 mu M). The A2780 cell lines included cisplatin-sensitive (sens) and -resistant (R) cells.

分类号： N

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