Characterization of a novel polysaccharide with anti-colon cancer activity from Lactobacillus helveticus MB2-1

文献类型： 外文期刊

第一作者： Li, Wei

作者： Li, Wei;Tang, Weizhi;Ji, Juan;Rui, Xin;Chen, Xiaohong;Jiang, Mei;Dong, Mingsheng;Xia, Xiudong;Zhou, Jianzhong

作者机构：

关键词： Lactobacillus helveticus MB2-1;Exopolysaccharides;Anti-colon cancer activity;Structural characterization;Methylated analysis;Nuclear magnetic resonance spectroscopy

期刊名称：CARBOHYDRATE RESEARCH （ 影响因子：2.104； 五年影响因子：2.192 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The present study aimed at investigating the potential anti-colon cancer activity of three purified exopolysaccharides fractions (LHEPS-1, LHEPS-2 and LHEPS-3) from the Lactobacillus helveticus MB2-1. The experimental evidence showed that LHEPS-1 significantly inhibited cell proliferation of human colon cancer Caco-2 cells in both time-and concentration-dependent manners. In contrast, no significant improvements of the inhibitory effects of LHEPS-2 and LHEPS-3 on Caco-2 cells were observed with increasing sample concentrations or prolonged incubation time. Furthermore, the structure of LHEPS-1 was elucidated using methylated analysis, gas chromatography-mass spectroscopy (GC-MS) and nuclear magnetic resonance spectroscopy (NMR), including one-and two-dimensional nuclear magnetic resonance (1D and 2D NMR). Results indicated that the LHEPS-1 consisted of a decasaccharide repeating unit with the following structure (n approximate to 122):

分类号： O62

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