Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy

文献类型： 外文期刊

第一作者： Liu, Jia

作者： Liu, Jia;Zheng, Lanhong;Liu, Jia;Wu, Ning;Liu, Ge;Lin, Xiukun;Ma, Leina;Wang, Bin;Zhao, Youguang;Lin, Xiukun

作者机构：

关键词： Oleanolic acid;Autophagy;Akt;Cancer prevention;Natural compounds

期刊名称：JOURNAL OF NUTRITIONAL BIOCHEMISTRY （ 影响因子：6.048； 五年影响因子：6.114 ）

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年卷期：

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收录情况： SCI

摘要： Oleanolic acid (OA) has been widely studied because of its pleiotropic therapeutic and preventive effect on various diseases. However, the mechanisms of OA's action are still not clear yet, especially its suppressing effect on transformed cells. In this work, we found that OA induced autophagy in normal tissue-derived cells without cytotoxicity. OA-induced autophagy was shown to decrease the proliferation of KRAS-transformed normal cells and to impair their invasion and anchorage-independent growth. Interrupting autophagy rescued OA's effect on the transformed cells. Mouse model experiments also demonstrated that OA suppressed the growth of KRAS-transformed breast epithelial cell MCF10A-derived tumor xenograft by inducing autophagy. Finally, we identified that OA induced autophagy in normal cells by inhibiting the activation of Akt/mTOR/S6K signaling. In conclusions, we found that OA treatment permitted normal cells to undergo autophagy. The induced autophagy was required for OA to prevent or delay the growth of transformed normal cells. (C) 2014 Published by Elsevier Inc.

分类号： Q5

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