Simple and Reproducible Two-Stage Agitation Speed Control Strategy for Enhanced Triterpene Production by Lingzhi or Reishi Medicinal Mushrooms, Ganoderma lucidum ACCC G0119 (Higher Basidiomycetes) Based on Submerged Liquid Fermentation

文献类型： 外文期刊

第一作者： Feng, Jie

作者： Feng, Jie;Feng, Na;Yang, Yan;Liu, Fang;Zhang, Jing-Song;Jia, Wei;Feng, Jie;Feng, Na;Yang, Yan;Liu, Fang;Zhang, Jing-Song;Jia, Wei;Lin, Chi-Chung

作者机构：

关键词： medicinal mushrooms;Ganoderma lucidum;batch fermentation;triterpenes;two-stage control strategy;agitation speed

期刊名称：INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS （ 影响因子：1.921； 五年影响因子：1.879 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Triterpenes are important anticancer agents produced by batch submerged liquid fermentation, with the medicinal mushroom Ganoderma lucidum ACCC G0119, which was investigated under various dissolved oxygen levels by varying agitation speeds. Three kinetic parameters were analyzed: specific mycelial growth rate (mu(smg)), specific glucose consumption rate (q(sgc)), and specific triterpene production rate (q(stp)). High concentration, yield, and productivity of triterpenes were achieved by developing a simple and reproducible two-stage agitation speed control strategy. At the first 40 h, agitation speed was controlled at 150 rpm to obtain the quickest peak qstp for triterpene production, subsequently agitation speed was controlled at 100 rpm to maintain high q(stp) for high triterpene accumulation. The maximum concentration of triterpenes reached 0.086 g/l with the yield of 6.072 g/kg and the productivity of 6.532 x 10(-4) g/(l.h), which were 39.61%, 36.48%, and 49.22%, respectively, better than the best results controlled by fixed agitation speeds. Conceivably, such a triterpene fermentation production strategy would be useful for industrial large-scale production of triterpenes with G. lucidum.

分类号： Q94

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