Actinotetraose L, a new tetrasaccharide derivative isolated from the mycelia of Amycolatopsis sp HCa1

文献类型： 外文期刊

第一作者： Guo, Zhi-Kai

作者： Guo, Zhi-Kai;Yan, Wei;Tan, Ren-Xiang;Ge, Hui-Ming

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关键词： Amycolatopsis;Pseudonocardiaceae;grasshopper;tetrasaccharide

期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）

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收录情况： SCI

摘要： A new tetrasaccharide derivative, actinotetraose L (1), was isolated from the methanol extract of the mycelia of the grasshopper-associated rare actinobacterium Amycolatopsis sp. HCa1. The structure of the new compound was elucidated by a combination of 1D, 2D NMR (HMQC, HMBC, COSY, and NOESY), and HR-ESI-MS analyses as O-{3,4-di-O-[(E)-2-ethyl-2-butenoyl]- beta-D-glucopyranosyl-(1 -> 2)}-O-{3,4-di-O-[(E)-2-methyl-2-butenoyl]-beta-D-glucopyranosyl-(1 -> 2)}-6,6-di-O-[(E)-2-methyl-2-butenoyl]-alpha-D-glucopyranosyl-(1 -> 1)-alpha-D-glucopyranoside. The immunosuppressive activity and cytotoxicity of the compound were evaluated by T-cell viability and MTT assays. Nonetheless, no significant activity was observed.

分类号： R9

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