2-(2-Phenylethyl)chromone derivatives in artificial agarwood from Aquilaria sinensis

文献类型： 外文期刊

第一作者： Mei, Wen-Li

作者： Mei, Wen-Li;Dong, Wen-hua;Li, Wei;Wang, Pei;Kong, Fan-Dong;Gai, Cui-Juan;Dai, Hao-Fu;Liao, Ge;Song, Xi-Qiang

作者机构：

关键词： Aquilaria sinensis;Agarwood;2-(2-Phenylethyl)chromone;Biological activity

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

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收录情况： SCI

摘要： Seven new 2-(2-phenylethyl)chromone derivatives (1-7) including a chlorinated one (4), together with eight known ones (8-15), were isolated from the EtOAc extract of artificial agarwood originating from Aquilaria sinensis (Lour.) Gilg. All structures including the absolute configurations were unambiguously elucidated by spectroscopic (NMR, UV, IR, MS) methods, Mosher's method, and comparison with reported data in the literatures. Among those, compounds 8, 12, and' 14 exhibited significant inhibition against a-glucosidase in vitro with IC50 values of 0.15, 0.05, and 0.09 mM, respectively (with acarbose as the positive control; IC50: 0.98 mM). In addition, compounds 3, 9, 11, and 14 showed weak inhibitory activity against AChE; and compounds 12 and 13 displayed weak cytotoxicity against human gastric cell line (SGC-7901) among three types of tested human cancer cell lines (BEL-7402, K562, and SGC-7901). (C) 2016 Elsevier B.V. All rights reserved.

分类号： S759.82

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