The application of directly suspended droplet microextraction for the evaluation of phthalic acid esters in cow's milk by gas chromatography mass spectrometry
文献类型: 外文期刊
第一作者: Liu, Dan
作者: Liu, Dan;Min, Shungeng;Song, Xiangzhong;Ping, Hua
作者机构:
关键词: Phthalic acid esters PAEs;Directly suspended droplet microextraction;DSDME;Milk
期刊名称:JOURNAL OF CHROMATOGRAPHY A ( 影响因子:4.759; 五年影响因子:4.302 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: A simple and rapid method was developed for evaluating 16 phthalic acid esters (PAEs) at the mu g/kg level in a complex milk matrix using directly suspended droplet microextraction-gas chromatography mass spectrometry (DSDME-GC-MS). The different parameters for extraction and for the DSDME experiment were optimized, including You are free to submit the revised manuscript at a later date as a new submission. 10 g/L trichloroacetic acid concentration, 100 mu L cyclohexane micro-droplet organic solvent, 1100 rpm stirring speed, 10 min extraction time and no salt amount. Validation experiments showed good linearity (gamma > 0.9878, 0.002-0.4 mu g/mL), satisfactory precision (RSD < 11%), and good accuracy (relative,recovery of 70.2-108%) when analyzing milk samples using the optimized method. The limits of detection (LODs) ranged between 0.001 and 0.2 mu g/L, and the limits of quantification (LOQs) ranged between 0.003 and 0.7 mu g/L. for 15 PAEs. Dinonyl phthalate (DINP) had a low response and did not have good linearity. The proposed method was successfully applied for the analysis of PAEs in real milk samples. (C) 2016 Elsevier B.V. All rights reserved.
分类号: O65
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