Toxicity of Tributyltin in Juvenile Common Carp (Cyprinus Carpio): Physiological Responses, Hepatic Gene Expression, and Stress Protein Profiling

文献类型： 外文期刊

第一作者： Li, Zhi-Hua

作者： Li, Zhi-Hua;Zhong, Li-Qiao;Mu, Wei-Na;Wu, Yan-Hua;Li, Zhi-Hua;Mu, Wei-Na;Wu, Yan-Hua

作者机构：

关键词： Tributyltin;Common Carp;Physiological Responses;Gene Expression;Protein Profiling

期刊名称：JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY （ 影响因子：3.642； 五年影响因子：3.222 ）

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收录情况： SCI

摘要： In this study, the effects of tributyltin (TBT) on biochemical parameters (antioxidant responses and Na+-K+-ATPase) in different tissues were investigated by using juvenile common carp (Cyprinus Carpio) as well as growth and ion regulation-related genes expression and stress-related proteins profiling in fish liver. Oxidative stress indices and Na+-K+-ATPase showed tissues-specific responses in fish exposed to different TBT concentrations. All tested genes related to GH/IGF-I axis and ion-regulation were significantly induced in the TBT group with lower concentrations (except for the igfbp3 in 10 g/L) and were inhibited in 20 g/L. In addition, the profiling of two proteins Hsp 70 and MT were increasing in a dose-dependent manner under TBT stress. In short, TBT-induced biochemical and molecular responses in different tissues were reflected in the measured parameters in the test. On the basis of TBT residue levels in the natural environment, more long-term experiments at lower concentrations will be necessary in the future.

分类号： Q5

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