Five new 5,11-epoxyguaiane sesquiterpenes in agarwood "Qi-Nan" from Aquilaria sinensis

文献类型： 外文期刊

第一作者： Yang, De-Lan

作者： Yang, De-Lan;Li, Wei;Dong, Wen-Hua;Wang, Jun;Mei, Wen-Li;Dai, Hao-Fu;Li, Wei;Dong, Wen-Hua;Mei, Wen-Li;Dai, Hao-Fu

作者机构：

关键词： Agarwood;Aquilaria sinensis;Qi-Nan;Guaianes;Fragrant sesquiterpene;AChE inhibitory activities

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Five new 5,11-epoxyguaiane sesquiterpenes (1-5), along with a known one (6) were isolated from high quality agarwood 'Qi-Nan' originating from Aquilaria sinensis. Their structures were established based on spectroscopic methods including IR, HR-ESI-MS, 1D, and 2D NMR. Compounds 1-6 were all 5,11-epoxyguaiane sesquiterpenes, sharing the same tetrahydrofuran ring by etherification of C-5 and C-11, and furthermore, functionalized at C-14 in the guaiane skeleton. All the six 5,11-epoxyguaianes (1-6) possess lasting fragrant smell at room temperature. This type of 5,11-epoxyguaiane sesquiterpenes were found to exist in agarwood 'Qi-Nan' only originating from A. sinensis rather than other species of the genus Aquilaria. These isolated guaiane sesquiterpenes showed acetyl cholinesterase inhibitory activities in different degrees ranged from 15% to 63% at the concentration of 50 mu g/mL. (C) 2016 Elsevier B.V. All rights reserved.

分类号： S759.82

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