Efficient porcine reproductive and respiratory syndrome virus entry in MARC-145 cells requires EGFR-PI3K-AKT-LIMK1-COFILIN signaling pathway

文献类型： 外文期刊

第一作者： Wang, Rui

作者： Wang, Rui;Wang, Xin;Ni, Bo;Huang, Li;Mao, Xiang;Liao, Ying;Tong, Guang-zhi;Ding, Chan;Mao, Xiang;Wu, Jia-qiang;Wen, Li-bing

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关键词： Porcine reproductive and respiratory;syndrome virus;Entry;Epidermal growth factor receptor;Cofilin

期刊名称：VIRUS RESEARCH （ 影响因子：3.303； 五年影响因子：3.445 ）

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收录情况： SCI

摘要： Viruses have evolved diverse strategies to take over cellular machinery to facilitate their infection. In our studies presented here, we first demonstrated that Src kinase was involved in PRRSV entry in MARC-145 cells. Further studies demonstrated epidermal growth factor receptor (EGFR) was activated by the currently unknown mechanism(s) during PRRSV entry, which subsequently initiated EGFR downstream signal pathways, such as PI3K/AKT/LIMK1. Through these pathways, the virus entry signal was ultimately transferred to cofilin, which might regulate the actin fragmentation and reorganization to facilitate the virus penetration and cytoplasmic trafficking. (C) 2016 Elsevier B.V. All rights reserved.

分类号： R37

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