Identification of a linear B-cell epitope on the avian leukosis virus P27 protein using monoclonal antibodies

文献类型: 外文期刊

第一作者: Li, Xiaofei

作者: Li, Xiaofei;Qi, Xiaole;Wang, Yongqiang;Gao, Honglei;Gao, Yulong;Wang, Xiaomei;Li, Xiaofei;Qin, Liting;Sun, Yingjun;Cui, Xuezhi;Gao, Yadong;Zhu, Haibo

作者机构:

关键词: avian leukosis virus;P27 protein;monoclonal antibodies;epitope

期刊名称:ARCHIVES OF VIROLOGY ( 影响因子:2.574; 五年影响因子:2.466 )

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收录情况: SCI

摘要: Avian leukosis virus (ALV) is an avian oncogenic retrovirus that can induce various clinical tumors. The capsid protein P27 is the group-specific antigen of ALV and has many viral antigen sites that are easy to detect. In this study, we produced a monoclonal antibody (mAb), 3A9, that is specific for the P27 protein. A series of partially overlapping peptides were screened to define (181)PPSAR(185) as the minimal linear epitope recognized by mAb 3A9. The identified epitope could be recognized by chicken anti-ALV and mouse anti-ALV P27 sera. The epitope was highly conserved among a number of ALV-A, ALV-B and ALV-J strains. MAb 3A9 might be a valuable tool for the development of new immunodiagnostic approaches for ALV, and the defined linear epitope might help further our understanding of the antigenic structure of the P27 protein.

分类号: R37

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