Unusual Cytotoxic Steroidal Saponins from the Gorgonian Astrogorgia dumbea

文献类型： 外文期刊

第一作者： Lu, Ya-Nan

作者： Lu, Ya-Nan;Tian, Xiao-Qing;Fan, Cheng-Qi;Cui, Ping;Lou, Li-Guang

作者机构：

关键词： Astrogorgia dumbea;Plexauridae;steroidal saponin;astrogorgiosides A-C;cytotoxic activity

期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Three steroidal saponins, including astrogorgiosides A (1) and B (2) bearing acetamido-glucose moieties, and astrogorgioside C (3) with a 19-nor and bearing an aromatized B ring steroid aglycone, together with a known major saponin dimorphoside A (4), were obtained from the gorgonian Astrogorgia dumbea collected near Dongshan Island in East China Sea. Structures of these compounds were elucidated by in-depth spectral and chemical methods, including 2D-NMR, HR-ESI-ESI-MS spectra, and acidic hydrolysis. For the first time, acetamido-glucose moiety is being reported from a gorgonian. The B-ring aromatized steroid aglycone of compound 3 is also rare in marine natural products. Compounds 1-3 exhibited moderate cytotoxic activity with IC50 values of 26.8-45.6 mu M against human tumor cells Bel-7402 and K562.

分类号： R9

  • 相关文献

[1]A new steroidal saponin from dragon's blood of Dracaena cambodiana. Luo, Ying,Shen, Hai-Yan,Zuo, Wen-Jian,Wang, Hui,Mei, Wen-Li,Dai, Hao-Fu,Luo, Ying. 2015

[2]Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation. Peng, Min,Shi, Liqiao,Ke, Shaoyong. 2017

[3]Homoisoflavonoids from the medicinal plant Portulaca oleracea. Yan, Jian,Zhou, Zhong-Yu,Tan, Jian-Wen,Sun, Li-Rong,Chen, Yu-Chan,Zhang, Wei-Min,Dai, Hao-Fu. 2012

[4]Cucurbitacins from fruits of Aquilaria sinensis. Dai Hao-Fu. 2012

[5]Caloxanthones O and P: Two New Prenylated Xanthones from Calophyllum inophyllum. Dai, Hao-Fu,Zeng, Yan-Bo,Xiao, Qi,Han, Zhuang,Mei, Wen-Li,Dai, Hao-Fu,Zeng, Yan-Bo,Mei, Wen-Li,Zhao, You-Xing. 2010

[6]New sesquiterpenoids from Aglaia odorata var. microphyllina and their cytotoxic activity. Liu, Shuai,Liu, Shou-Bai,Zuo, Wen-Jian,Guo, Zhi-Kai,Mei, Wen-Li,Dai, Hao-Fu.

[7]Antioxidant and Cytotoxic Phenolic Compounds of Areca Nut(Areca catechu). Zhang Xing,Wu Jiao,Han Zhuang,Mei Wen-li,Dai Hao-fu. 2010

[8]Identification of tyrosine 71 as a critical residue for the cytotoxic activity of Clostridium perfringens epsilon toxin towards MDCK cells. Jiang, Zhigang,Chang, Jitao,Wang, Fang,Yu, Li. 2015

[9]Three new cyclopentenone derivatives from Actinoalloteichus nanshanensis NEAU 119. Zhang, Ji,Liu, Chong-Xi,Xiang, Wen-Sheng,Qian, Ping-Ting,Wang, Ji-Dong,Xiang, Wen-Sheng.

[10]Aquilarin A, a New Benzenoid Derivative from the Fresh Stem of Aquilaria sinensis. Peng, Ke,Dai, Hao-Fu,Wang, Qing-Huang,Tan, Le-He. 2010

[11]Cytotoxicity evaluation of coumarin derivatives containing 4-bromophenyl or anthracene moieties. Zhang, Hui,Zhao, Ming,Yu, Tianzhi,Fan, Duowang,Zhao, Ming,Zhao, Yuling,Zhang, Shidong.

[12]Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum. Huang, Sheng-Zhuo,Ma, Qing-Yun,Kong, Fan-Dong,Guo, Zhi-Kai,Cai, Cai-Hong,Hu, Li-Li,Zhou, Li-Man,Wang, Qi,Dai, Hao-Fu,Mei, Wen-Li,Zhao, You-Xing. 2017

[13]Preparative Isolation of Two Prenylated Biflavonoids from the Roots and Rhizomes of Sinopodophyllum emodi by Sephadex LH-20 Column and High-Speed Counter-Current Chromatography. Sun, Yan-Jun,Pei, Li-Xin,Wang, Jun-Min,Zhang, Yan-Li,Gao, Mei-Ling,Ji, Bao-Yu,Sun, Yan-Jun,Pei, Li-Xin,Wang, Jun-Min,Zhang, Yan-Li,Gao, Mei-Ling,Ji, Bao-Yu,Wang, Kai-Bo,Wang, Kai-Bo,Sun, Yin-Shi.

[14]A novel degraded sesquiterpene from the fresh stem of Aquilaria sinensis. Peng, Ke,Tan, Le-He,Wang, Qing-Huang,Dai, Hao-Fu,Peng, Ke,Mei, Wen-Li,Zhao, You-Xing,Dai, Hao-Fu,Peng, Ke. 2011

[15]Cytotoxic prenylated xanthones from Calophyllum inophyllum. Xiao, Qi,Zeng, Yan-Bo,Mei, Wen-Li,Deng, Yuan-Yuan,Dai, Hao-Fu,Zhao, You-Xing. 2008

[16]Phenolic compounds from Dalbergia odorifera. Wang, Hao,Mei, Wen-li,Zeng, Yan-bo,Zuo, Wen-jian,Guo, Zhi-kai,Chen, Liang-liang,Dai, Hao-fu,Wang, Hao,Zhong, Hui-min.

[17]New serratene triterpenoids from Palhinhaea cernua and their cytotoxic activity. Yan, Jian,Zhou, Zhong-Yu,Zhang, Mei,Wang, Jing,Tan, Jian-Wen,Dai, Hao-Fu,Zhang, Mei,Wang, Jing.

[18]Three new phenolic compounds from Dalbergia odorifera. Wang, Hao,Dong, Wen-Hua,Zuo, Wen-Jian,Wang, Hui,Mei, Wen-Li,Dai, Hao-Fu,Wang, Hao,Zhong, Hui-Min.

[19]Wortmannines A-C, three novel wortmannin derivatives with an unusual five-membered B ring from the endophytic fungus Talaromyces wortmannii LGT-4. Fu, Guang-Chao,Yang, Zhong-Duo,Shu, Zong-Mei,Xue, Hong-Yan,Wang, Yong-Gang,Yang, Zhong-Duo,Zhou, Shuang-Yan,Yao, Xiao-Jun,Li, Xin-Ming,Fang, Jian-Guo,Li, Xin-Ming,Fang, Jian-Guo,Yu, Hai-Tao.

[20]Acylhydrazone derivatives as potential anticancer agents: Synthesis, bio-evaluation and mechanism of action. Yu, Xifang,Shi, Liqiao,Ke, Shaoyong.

作者其他论文 更多>>

微信小程序