Parapoxvirus orf virus infection induces an increase in interleukin-8, tumour necrosis factor-alpha, and decorin in goat skin fibroblast cells

文献类型： 外文期刊

第一作者： Wang, Lingling

作者： Wang, Lingling;Lu, Bingzhou;Zheng, Haixue;Zhang, Keshan;Liu, Xiangtao

作者机构：

关键词： goat skin fibroblasts;orf virus;cytokines

期刊名称：JOURNAL OF VETERINARY RESEARCH （ 影响因子：1.744； 五年影响因子：1.838 ）

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年卷期：

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收录情况： SCI

摘要： Introduction: Orf virus (ORFV) is a prototype Parapoxvirus species in the Poxviridae family that causes serious zoonotic infectious disease. Goat skin fibroblast (GSF) cells are the major host targets of ORFV. Interleukin 8 (IL-8) and tumour necrosis factor (TNF)-alpha are known to play a vital role in immune response during viral infections. However, the manner of variation over time of their level of expression in GSF cells remains unclear. Material and Methods: In this study, quantitative enzyme-linked immunosorbent assay chips were used to detect changes in the levels of these cytokines expressed and secreted in GSF cells after ORFV infection. Results: Results showed that the expression of IL-8, TNF-alpha, and decorin was upregulated in the cell lysates, and that secreted decorin and IL-8 were significantly increased in cell supernatant. Conclusion: The results provided possible approaches to elucidation of how ORFV infection initiates host cell immune response.

分类号： S85

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