Protective Role of Selenium on Aflatoxin B-1-Induced Hepatic Dysfunction and Apoptosis of Liver in Ducklings

文献类型： 外文期刊

第一作者： Liao, Shenquan

作者： Liao, Shenquan;Shi, Dayou;Guo, Shining;Su, Rongsheng;Qiang, Panjia;Tang, Zhaoxin;Shi, Dayou;Guo, Shining;Su, Rongsheng;Qiang, Panjia;Tang, Zhaoxin;Shi, Dayou;Guo, Shining;Su, Rongsheng;Qiang, Panjia;Tang, Zhaoxin;Clemons-Chevis, Connie L.

作者机构：

关键词： Aflatoxins B-1;Selenium;Hepatic dysfunction;Apoptosis

期刊名称：BIOLOGICAL TRACE ELEMENT RESEARCH （ 影响因子：3.738； 五年影响因子：3.44 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Aflatoxin B-1 (AFB(1)) is a mycotoxin which causes toxicity through oxidative damage. Selenium (Se), an antioxidative agent, can antagonize some toxicity induced by oxidative stress. The aim of this work was to investigate the toxicity of AFB(1) and the protective effects of Se on duckling liver in vivo. The study consisted of three groups: AFB(1), AFB(1)Tx, and a control group. AFB(1) group was administered aflatoxin intragastrically (0.1 mg/kg body weight). AFB(1)Tx group was administered AFB(1) intragastrically (0.1 mg/kg body weight) plus sodium selenite (1 mg/kg body weight). The control group was given the same volume of dimethyl sulfoxide (DMSO) via intragastric intubation. All three groups received daily administrations for 28 days. Blood samples were obtained on the 14th, 21st, and 28th days of post-administration, and the serum alanine aminotransferase (ALT) and aspartate transaminase (AST) were evaluated. A high level of serum ALT and AST was observed in AFB(1) group. The activity of ALT and AST was significantly lower in Se treatment group than those in AFB(1) group. Liver samples were collected on the 14th, 21st, and 28th days of post-administration, and concentrations of Bcl-2, Bax, caspase-3, and p53 were measured. Increased expression level of Bax, caspase-3, and p53 and decreased Bcl-2 expression level and Bcl-2/Bax ratio were observed in AFB(1) group. Se diminished hepatic dysfunction, or damage and modulated the expression of apoptotic related proteins, in a time-dependent manner. In conclusion, concurrent treatment with Se reduced the AFB(1)-induced hepatic dysfunction and apoptosis.

分类号： Q5

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