A New Cytotoxic Stigmasterone from Agathis macrophylla

文献类型： 外文期刊

第一作者： Li, Ya

作者： Li, Ya;Gao, Kun;Wang, Tong-Tong

作者机构：

关键词： Agathis macrophylla;Stigmasterone;Cytotoxicity

期刊名称：NATURAL PRODUCT COMMUNICATIONS （ 影响因子：0.986； 五年影响因子：1.068 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： A new stigmasterone 7 alpha,15 alpha-dihydroxystigmast-4-en-3-one (1), along with fifteen known compounds was isolated from the EtOAc and n-BuOH fractions of the EtOH extract of Agathis macrophylla. The structure of these compounds 1-16 were established mainly by spectroscopic analysis and by comparison of the spectroscopic data with those reported for structurally related compounds. The isolated compounds 1-8 were screened for cytotoxicity in A549 tumor cell line using RSB assay. Compounds 1 and 2 displayed moderate cytotoxicity against A549 tumor cell line with IC50 value of 36.5 and 16.0 mu mol/L, respectively.

分类号： N

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