Inactivated Recombinant Rabies Viruses Displaying Canine Distemper Virus Glycoproteins Induce Protective Immunity against Both Pathogens

文献类型： 外文期刊

第一作者： Budaszewski, Renata da Fontoura

作者： Budaszewski, Renata da Fontoura;Budaszewski, Renata da Fontoura;Sawatsky, Bevan;Kraemer, Beate;von Messling, Veronika;Sawatsky, Bevan;von Messling, Veronika;Hudacek, Andrew;Yin, Xiangping;Schnell, Matthias J.;Yin, Xiangping

作者机构：

关键词： antibody responses;bivalent vaccine;canine distemper virus;ferret model;rabies virus;wildlife species

期刊名称：JOURNAL OF VIROLOGY （ 影响因子：5.103； 五年影响因子：5.078 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The development of multivalent vaccines is an attractive methodology for the simultaneous prevention of several infectious diseases in vulnerable populations. Both canine distemper virus (CDV) and rabies virus (RABV) cause lethal disease in wild and domestic carnivores. While RABV vaccines are inactivated, the liveattenuated CDV vaccines retain residual virulence for highly susceptible wildlife species. In this study, we developed recombinant bivalent vaccine candidates based on recombinant vaccine strain rabies virus particles, which concurrently display the protective CDV and RABV glycoprotein antigens. The recombinant viruses replicated to near-wild-type titers, and the heterologous glycoproteins were efficiently expressed and incorporated in the viral particles. Immunization of ferrets with beta-propiolactone-inactivated recombinant virus particles elicited protective RABV antibody titers, and animals immunized with a combination of CDV attachment protein-and fusion protein-expressing recombinant viruses were protected from lethal CDV challenge. However, animals that were immunized with only a RABV expressing the attachment protein of CDV vaccine strain Onderstepoort succumbed to infection with a more recent wild-type strain, indicating that immune responses to the more conserved fusion protein contribute to protection against heterologous CDV strains.

分类号： Q934.2

  • 相关文献

[1]Recombinant rabies virus expressing the H protein of canine distemper virus protects dogs from the lethal distemper challenge. Wang, Feng-Xue,Zhang, Shu-Qin,Zhu, Hong-Wei,Yang, Yong,Sun, Na,Tan, Bin,Li, Zhen-Guang,Cheng, Shi-Peng,Wen, Yong-Jun,Li, Zhen-Guang,Fu, Zhen F..

[2]Recombinant Bivalent Vaccine against Foot-and-Mouth Disease Virus Serotype O/A Infection in Guinea Pig. Yi, JZ,Liu, MQ,Zhu, CZ,Zhang, Q,Sheng, ZT,Du, QY,Yan, WY,Zheng, ZX.

[3]Safety and immunogenicity of a gE/gI/TK gene-deleted pseudorabies virus variant expressing the E2 protein of classical swine fever virus in pigs. Lei, Jian-Lin,Xia, Shui-Li,Wang, Yimin,Du, Mingliang,Xiang, Guang-Tao,Cong, Xin,Luo, Yuzi,Li, Lian-Feng,Zhang, Lingkai,Yu, Jiahui,Qiu, Hua-Ji,Sun, Yuan,Lei, Jian-Lin,Hu, Yonghao.

[4]Secreted Expression of the Cap Gene of Porcine Circovirus Type 2 in Classical Swine Fever Virus C-Strain: Potential of C-Strain Used as a Vaccine Vector. Zhang, Lingkai,Li, Yongfeng,Xie, Libao,Wang, Xiao,Sun, Yuan,Qiu, Hua-Ji,Gao, Xulei. 2017

[5]Characterization of a new dog isolate of canine distemper virus from China. Qiao, J.,Meng, Q.,Chen, C.,Xia, X.,Ren, Y.,Zhang, H.,Qiao, J.,Cai, X.. 2011

[6]Development of a combined canine distemper virus specific RT-PCR protocol for the differentiation of infected and vaccinated animals (DIVA) and genetic characterization of the hemagglutinin gene of seven Chinese strains demonstrated in dogs. Yi, Li,Cheng, Shipeng,Xu, Hongli,Wang, Jianke,Cheng, Yuening,Yang, Shen,Luo, Bin. 2012

[7]Recombinant Newcastle disease viral vector expressing hemagglutinin or fusion of canine distemper virus is safe and immunogenic in minks. Ge, Jinying,Wang, Xijun,Tian, Meijie,Wen, Zhiyuan,Yu, Guimei,Zhou, Weiwei,Zu, Shulong,Bu, Zhigao,Gao, Yuwei.

[8]Identification of a novel canine distemper virus B-cell epitope using a monoclonal antibody against nucleocapsid protein. Yi, Li,Cheng, Yuening,Zhang, Miao,Cao, Zhigang,Tong, Mingwei,Wang, Jianke,Zhao, Hang,Lin, Peng,Cheng, Shipeng.

[9]Isolation and sequence analysis of a canine distemper virus from a raccoon dog in Jilin Province, China. Cheng, Yuening,Wang, Jianke,Zhang, Miao,Zhao, Jianjun,Shao, Xiqun,Zhao, Hang,Lin, Peng,Wu, Hua,Ma, Zengjun.

[10]Pathogenesis of canine distemper virus in experimentally infected raccoon dogs, foxes, and minks. Zhao, Jianjun,Shi, Ning,Sun, Yangang,Zhu, Chunsheng,Zhang, Hailing,Hu, Bo,Bai, Xue,Yan, Xijun,Zhao, Jianjun,Yan, Xijun,Martella, Vito,Nikolin, Veljko.

[11]Identification of a novel linear B-cell epitope using a monoclonal antibody against the carboxy terminus of the canine distemper virus nucleoprotein and sequence analysis of the identified epitope in different CDV isolates. Yi, Li,Cao, Zhigang,Tong, Mingwei,Cheng, Yuening,Li, Shuang,Wang, Jianke,Lin, Peng,Sun, Yaru,Zhang, Miao,Cheng, Shipeng,Yang, Yong. 2017

[12]Phylogenetic analysis of the haemagglutinin gene of canine distemper virus strains detected from breeding foxes, raccoon dogs and minks in China. Zhao, Jian-Jun,Yan, Xi-Jun,Chai, Xiu-Li,Luo, Guo-Liang,Zhang, Hai-Ling,Gao, Han,Bai, Xue,Zhang, Lei,Chen, Tao,Xu, Lei,Zhao, Chun-Fei,Wang, Feng-Xue,Shao, Xi-Qun,Wu, Wei,Cheng, Shi-Peng,Martella, Vito,Liu, Ying-Xue.

[13]Emergence of canine distemper virus strains with two amino acid substitutions in the haemagglutinin protein, detected from vaccinated carnivores in North-Eastern China in 2012-2013. Zhao, Jianjun,Zhang, Hailing,Bai, Xue,Hu, Bo,Sun, Yangang,Zhu, Chunsheng,Zhang, Lei,Liu, Hao,Xu, Shujuan,Shao, Xiqun,Wu, Wei,Yan, Xijun,Zhao, Jianjun,Yan, Xijun,Martella, Vito. 2014

[14]Development and characterization of neutralizing monoclonal antibodies against canine distemper virus hemagglutinin protein. Bi, Zhenwei,Xia, Xingxia,Wang, Yongshan,Mei, Yongjie,Bi, Zhenwei,Xia, Xingxia,Wang, Yongshan,Mei, Yongjie.

[15]Phylogenetic analysis of canine distemper virus in domestic dogs in Nanjing, China. Bi, Zhenwei,Wang, Yongshan,Wang, Xiaoli,Xia, Xingxia,Bi, Zhenwei,Wang, Yongshan,Wang, Xiaoli,Xia, Xingxia,Bi, Zhenwei,Wang, Yongshan,Wang, Xiaoli,Xia, Xingxia,Bi, Zhenwei,Wang, Yongshan,Wang, Xiaoli,Xia, Xingxia.

[16]Development of CDV-specific monoclonal antibodies for differentiation of variable epitopes of nucleocapsid protein. Bi, Zhenwei,Wang, Yongshan,Pan, Qunxing,Xia, Xingxia,Bi, Zhenwei,Wang, Yongshan,Pan, Qunxing,Xia, Xingxia,Xu, Libo.

[17]Chimeric rabies glycoprotein with a transmembrane domain and cytoplasmic tail from Newcastle disease virus fusion protein incorporates into the Newcastle disease virion at reduced levels. Yu, Gui Mei,Zu, Shu Long,Zhou, Wei Wei,Wang, Xi Jun,Shuai, Lei,Wang, Xue Lian,Ge, Jin Ying,Bu, Zhi Gao. 2017

[18]Seroprevalence of Rabies Virus Antibodies in Bats from Southern China. Jiang, Yu,Wang, Lili,Han, Xiaohu,Xia, Xianzhu,Tu, Changchun,Wang, Lili,Zhao, Fuguang,Lu, Zongji,Xuan, Hua. 2010

[19]An inactivated recombinant rabies CVS-11 virus expressing two copies of the glycoprotein elicits a higher level of neutralizing antibodies and provides better protection in mice. Xue, Xiang-Hong,Li, Ling,Yang, Song-Tao,Xia, Xian-Zhu,Xue, Xiang-Hong,Zheng, Xue-Xing,Wang, Hua-Lei,Ma, Jin-Zhu,Li, Ling,Gai, Wei-Wei,Wang, Tie-Cheng,Yang, Song-Tao,Xia, Xian-Zhu,Zheng, Xue-Xing,Ma, Jin-Zhu.

[20]Rabies virus nucleoprotein expressed in silkworm pupae at high-levels and evaluation of immune responses in mice. Yin, Xiangping,Li, Zhiyong,Li, Jiangtao,Zhang, Yun,Li, Xuerui,Li, Baoyu,Yang, Bin,Lan, Xi,Jiao, Wenqiang,Liu, Jixing,Yi, Yongzhu,Li, Yinv,Zhang, Zhifang.

作者其他论文 更多>>

微信小程序