Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections

文献类型： 外文期刊

第一作者： Li, Zhenguang

作者： Li, Zhenguang;He, Minghui;Wang, Jiangke;Cheng, Shipeng;Li, Zhenguang;Wu, Hua;Xu, Xiaoqin;Leng, Xue

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期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）

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收录情况： SCI

摘要： Several biological processes as well as infectious agents, physiological or environmental stress, and perturbed antioxidant response can promote oxidative stress. Oxidative stress usually happens when cells are exposed to more electrically charged reactive oxygen species (ROS) such as H2O2 or O-2 (-). ROS are well known for being both beneficial and deleterious. Recent studies have indicated that ROS are deleterious to cells, leading to programmed cell death (PCD) at high concentrations. At low concentrations, however, ROS can act as signaling molecules in a variety of cellular processes. In this review, we present an update of our current understanding of the role and regulation of reactive oxygen species in various viral infections, cellular signaling pathways and immune responses. We then discuss how the antioxidant defense system acts as an antiviral effector to limit cell damage.

分类号： R37

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