Recombinant Newcastle disease virus expressing the infectious bronchitis virus S1 gene protects chickens against Newcastle disease virus and infectious bronchitis virus challenge

文献类型： 外文期刊

第一作者： Zhao, Ran

作者： Zhao, Ran;Sun, Junfeng;Qi, Tianming;Zhao, Wen;Han, Zongxi;Liu, Shengwang;Zhao, Ran;Yang, Xiaopu;Liu, Shengwang

作者机构：

关键词： Bivalent vaccine candidate;Infectious bronchitis virus;LX4 genotype;Newcastle disease virus;Recombinant LaSota strain

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN：

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收录情况： SCI

摘要： The recombinant LaSota strain expressing a chimeric IBV S1 gene (rLaSota-S1) was constructed with the S1 gene of the LX4 type IBV ck/CH/LDL/091022. The expression of the S1 protein was detected by an indirect immunofluorescence assay and Western blotting. The rLaSota-S1 strain was slightly attenuated, and its growth dynamics were similar to that of the parental LaSota strain. Vaccination of specific pathogen free chickens with the rLaSota-S1 strain induced NDV hemagglutination inhibition antibodies, and it protected chickens from challenge with virulent NDV. In addition, vaccination with the rLaSota-S1 strain induced IBV-specific IgG antibodies and cellular immunity; however, a single vaccination provided partial protection with reduced virus shedding. Better protection efficiency was observed after a booster vaccination, which resulted in higher antibody titers, significantly fewer disease symptoms, and reduced virus replication and shedding. Our results suggest that the rLaSota-S1 strain is a bivalent vaccine candidate against both NDV and IBV. (C) 2017 Elsevier Ltd. All rights reserved.

分类号： R392

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