Inhibition of bone formation in rats by aluminum exposure via Wnt/beta-catenin pathway

文献类型: 外文期刊

第一作者: Sun, Xudong

作者: Sun, Xudong;Wang, Haoran;Huang, Wanyue;Yu, Hongyan;Shen, Tongtong;Song, Miao;Han, Yanfei;Li, Yanfei;Zhu, Yanzhu

作者机构:

关键词: Aluminum trichloride;Bone formation;Wnt/beta-catenin signaling pathway;Rat

期刊名称:CHEMOSPHERE ( 影响因子:7.086; 五年影响因子:6.956 )

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收录情况: SCI

摘要: The previous research found that aluminum trichloride (AlCl3) inhibited rat osteoblastic differentiation through inactivation of Wnt/beta-catenin signaling pathway in vitro. On that basis, the experiment in vivo was conducted in this study. Rats were orally exposed to 0 (control group) and 0.4 g/L AlCl3 (AlCl3-treated group) for 30, 60, 90 or 120 days, respectively. We found that mRNA expressions of type I collagen and insulin-like growth factor-1, mRNA and protein expressions of Runx2 and survivin, ratio of p-GSK3 beta/GSK3 beta and protein expression of (l-catenin were all decreased, whereas the mRNA and protein expressions Dkk1 and sFRP1 and the mRNA expressions and activity of Caspase-3 were increased in the AlCl3 treated group compared with the control group with time prolonged. These results suggest that A1Cl(3) inhibits bone formation and induces bone impairment by inhibiting the Wnt/beta-catenin signaling pathway in young growing rats. (C) 2017 Elsevier Ltd. All rights reserved.

分类号: X5

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