Quantification of Piperazine in Chicken Muscle by Ultra-Performance Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry

文献类型： 外文期刊

第一作者： Xie, Kaizhou

作者： Xie, Kaizhou;Liu, Ya'nan;Sun, Lirui;Gao, Qiang;Wang, Bo;Zhang, Yangyang;Zhang, Genxi;Dai, Guojun;Wang, Jinyu;Xie, Kaizhou;Liu, Ya'nan;Sun, Lirui;Gao, Qiang;Wang, Bo;Zhang, Yangyang;Zhang, Genxi;Dai, Guojun;Wang, Jinyu;Xie, Kaizhou;Liu, Ya'nan;Sun, Lirui;Gao, Qiang;Wang, Bo;Zhang, Yangyang;Zhang, Genxi;Dai, Guojun;Wang, Jinyu;Pang, Maoda;Xie, Xing;Wang, Ran

作者机构：

关键词： Piperazine;UPLC-ESI/MS/MS;Chickenmuscle

期刊名称：FOOD ANALYTICAL METHODS （ 影响因子：3.366； 五年影响因子：3.07 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： An ultra-performance liquid chromatography-electrospray ionization tandem triple quadrupole mass spectrometry (UPLC-ESI/MS/MS) method was developed for the detection of piperazine in chicken muscle. Following extraction and purification, the chicken muscle extract was injected into the UPLC system and analyzed. Piperazine detection was performed on a triple-quadrupole mass spectrometer with the ESI interface operating in positive mode. The most sensitive mass transition from the precursor ion to the product ion was 87.1 -> 44.1 for piperazine. The coefficient (R-2) of piperazine was 0.9995 in the range of 1-200 mu g/kg. The recovery and relative standard deviation (RSD) ranged from 102.93 to 111.46% and from 4.57 to 5.28% at 50.0, 100.0 and 200.0 mu g/kg adding levels, respectively. Limits of detection (LODs) and limits of quantification (LOQs) were 0.4 and 1.0 mu g/kg, respectively. This method was fully validated based on its specificity, sensitivity, linearity, precision, accuracy, matrix effect, and stability results. Compared to other researches, this new method not only omitted the derivative process, which simplify the pre-processing, but also proved a better sensitivity based on its low LOD and LOQ values.

分类号： TS2

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