HIV-1 susceptibility of transgenic rat-derived primary macrophage/T cells and a T cell line that express human receptors, CyclinT1 and CRM1 genes

文献类型： 外文期刊

第一作者： Shida, Hisatoshi

作者： Shida, Hisatoshi;Okada, Hiroyuki;Suzuki, Hajime;Zhang, Xianfeng;Chen, Jing;Tsunetsugu-Yokota, Yasuko;Tanaka, Yuetsu;Yakushiji, Fumika;Hayashi, Yoshio;Shida, Hisatoshi;Okada, Hiroyuki;Suzuki, Hajime;Zhang, Xianfeng;Yakushiji, Fumika

作者机构：

期刊名称：GENES TO CELLS （ 影响因子：1.891； 五年影响因子：2.069 ）

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收录情况： SCI

摘要： We developed transgenic (Tg) rats that express human CD4, CCR5, CXCR4, CyclinT1, and CRM1 genes. Tg rat macrophages were efficiently infected with HIV-1 and supported production of infectious progeny virus. By contrast, both rat primary CD4(+) T cells and established T cell lines expressing human CD4, CCR5, CyclinT1, and CRM1 genes were infected inefficiently, but this was ameliorated by inhibition of cyclophilin A. The infectivity of rat T cell-derived virus was lower than that of human T cell-derived virus.

分类号： R394

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