Rifamorpholines A-E, potential antibiotics from locust-associated actinobacteria Amycolatopsis sp Hca4
文献类型： 外文期刊
第一作者： Xiao, Yong Sheng
作者： Xiao, Yong Sheng;Zhang, Bo;Zhang, Mei;Guo, Zhi Kai;Deng, Xin Zhao;Shi, Jing;Li, Wei;Jiao, Rui Hua;Tan, Ren Xiang;Ge, Hui Ming;Guo, Zhi Kai
作者机构：
期刊名称：ORGANIC & BIOMOLECULAR CHEMISTRY （ 影响因子：3.876； 五年影响因子：3.397 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： Cultivation of locust associated rare actinobacteria, Amycolatopsis sp. HCa4, has provided five unusual macrolactams rifamorpholines A-E. Their structures were determined by interpretation of spectroscopic and crystallographic data. Rifamorpholines A-E possess an unprecedented 5/6/6/6 ring chromophore, representing a new subclass of rifamycin antibiotics. The biosynthetic pathway for compounds 1-5 involves a key 1,6-cyclization for the formation of the morpholine ring. Compounds 2 and 4 showed potent activities against methicillin-resistant Staphylococcus aureus (MRSA) with MICs of 4.0 and 8.0 mu M, respectively.
分类号： O64
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