Rifamorpholines A-E, potential antibiotics from locust-associated actinobacteria Amycolatopsis sp Hca4
文献类型： 外文期刊
第一作者： Xiao, Yong Sheng
作者： Xiao, Yong Sheng;Zhang, Bo;Zhang, Mei;Guo, Zhi Kai;Deng, Xin Zhao;Shi, Jing;Li, Wei;Jiao, Rui Hua;Tan, Ren Xiang;Ge, Hui Ming;Guo, Zhi Kai
作者机构：
期刊名称：ORGANIC & BIOMOLECULAR CHEMISTRY （ 影响因子：3.876； 五年影响因子：3.397 ）
ISSN：
年卷期：
页码：
收录情况： SCI
摘要： Cultivation of locust associated rare actinobacteria, Amycolatopsis sp. HCa4, has provided five unusual macrolactams rifamorpholines A-E. Their structures were determined by interpretation of spectroscopic and crystallographic data. Rifamorpholines A-E possess an unprecedented 5/6/6/6 ring chromophore, representing a new subclass of rifamycin antibiotics. The biosynthetic pathway for compounds 1-5 involves a key 1,6-cyclization for the formation of the morpholine ring. Compounds 2 and 4 showed potent activities against methicillin-resistant Staphylococcus aureus (MRSA) with MICs of 4.0 and 8.0 mu M, respectively.
分类号： O64
- 相关文献
作者其他论文 更多>>
-
Comparative analysis of the structural and compositional change of spotted sea bass (Lateolabrax maculatus) gut microflora following Aeromonas veronii infection and the effects of Lactobacillus plantarum on these changes
作者：Lin, Changhong;Lin, Changhong;Lin, Changhong;Zhang, Bo;Zhang, Boa;Qiu, Lihua;Zhang, Bo;Wang, Pengfei;Zhang, Boa;Yan, Lulu;Zhao, Chao;Qiu, Lihua;Zhang, Bo;Wang, Pengfei;Zhang, Boa;Yan, Lulu;Zhao, Chao;Qiu, Lihua;Zhang, Bo;Wang, Pengfei;Zhang, Boa;Zhao, Chao;Zhao, Chao
关键词：Lateolabrax maculatus; Aeromonas veronii; Gut microbiota; intestinal flora; pathogen.
-
Evaluating the Impact of an Organic Trace Mineral mix on the Redox Homeostasis, Immunity, and Performance of Sows and their Offspring
作者：Wang, Shao-Qing;Peng, Zhe;Sun, Hua;Sun, Lv-hui;Deng, Zhang-Chao;Sun, Hua;Han, Yan-Ming;Zhang, Bo;Pineda, Lane;Boerboom, Gavin;Liu, Ying
关键词：Sow performance; Piglet; Trace mineral; Redox homeostasis; Immunity
-
Histone H3 N-Terminal Lysine Acetylation Governs Fungal Growth, Conidiation, and Pathogenicity through Regulating Gene Expression in Fusarium pseudograminearum
作者：Jiang, Hang;Ma, Liguo;Qi, Kai;Zhang, Yueli;Zhang, Bo;Ma, Guoping;Qi, Junshan;Yuan, Lifang
关键词：histone acetylation; Fusarium crown rot; phytopathogen; H3 N-terminal lysine residues; gene expression
-
Integrative analysis of metabolome and transcriptome reveals regulatory mechanisms of flavonoid biosynthesis in soybean under salt stress
作者：Wang, Yubin;Liu, Wei;Li, Wei;Wang, Caijie;Dai, Haiying;Xu, Ran;Zhang, Yanwei;Zhang, Lifeng;Wang, Yubin;Liu, Wei;Li, Wei;Wang, Caijie;Dai, Haiying;Xu, Ran;Zhang, Yanwei;Zhang, Lifeng
关键词：soybean; salt stress; metabolome; transcriptome; flavonoid; regulatory mechanism
-
Two unprecedented 2-(2-phenethyl)chromone dimers from red soil agarwood of Aquilaria crassna
作者：Chai, Hong-Xing;Jiang, Bei;Dai, Hao-Fu;Chai, Hong-Xing;Wang, Hao;Zeng, Jun;Dong, Wen-Hua;Mei, Wen-Li;Li, Wei;Dai, Hao-Fu;Wang, Hao;Zeng, Jun;Dong, Wen-Hua;Mei, Wen-Li;Li, Wei;Dai, Hao-Fu
关键词：Aquilaria crassna; Red soil agarwood; 2-(2-Phenylethyl)chromone dimers; Anti-inflammatory activity
-
Naringin's Alleviation of the Inflammatory Response Caused by Actinobacillus pleuropneumoniae by Downregulating the NF-κB/NLRP3 Signalling Pathway
作者：Huang, Qilin;Jing, Xiaohan;Liu, Chen;Ahmad, Saad;Zhao, Guanyu;Li, Zhaorong;Qiu, Zhengying;Xin, Ruihua;Huang, Qilin;Jing, Xiaohan;Liu, Chen;Ahmad, Saad;Zhao, Guanyu;Li, Zhaorong;Qiu, Zhengying;Xin, Ruihua;Huang, Qilin;Jing, Xiaohan;Liu, Chen;Ahmad, Saad;Zhao, Guanyu;Li, Zhaorong;Qiu, Zhengying;Xin, Ruihua;Li, Wei;Huang, Lina
关键词：Actinobacillus pleuropneumoniae (APP); inflammatory injury; NLRP3 inflammasome; protein interactions; naringin (NAR); anti-inflammatory mechanism
-
The nematode effector calreticulin competes with the high mobility group protein OsHMGB1 for binding to the rice calmodulin-like protein OsCML31 to enhance rice susceptibility to Meloidogyne graminicola
作者：Liu, Jing;Zhang, Jiaqian;Wei, Ying;Su, Wen;Li, Wei;Wang, Bing;Dai, Liangying;Liu, Jing;Gheysen, Godelieve;Zhang, Jiaqian;Wei, Ying;Peng, Deliang;Peng, Huan;Peng, Huan;Dai, Liangying
关键词：calmodulin-like protein; calreticulin; effector; Meloidogyne graminicola; OsHMGB1; plant defense
