Phenolic Fractions from Muscadine Grape "Noble" Pomace can Inhibit Breast Cancer Cell MDA-MB-231 Better than those from European Grape "Cabernet Sauvignon" and Induce S-Phase Arrest and Apoptosis

文献类型: 外文期刊

第一作者: Wei, Zheng

作者: Wei, Zheng;Zhang, Shengyu;Zhang, Yali;Luo, Jianming;Peng, Xichun;Wei, Zheng;Huang, Yu;Lu, Jiang;Lu, Jiang

作者机构:

关键词: apoptosis;breast cancer cell;cell cycle;ellagic acid;muscadine grape pomace

期刊名称:JOURNAL OF FOOD SCIENCE ( 影响因子:3.167; 五年影响因子:3.376 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Tons of grape pomace which still contained a rich amount of plant polyphenols, is discarded after winemaking. Plant polyphenols have multi-functional activities for human body. In this study, polyphenols of pomaces from Muscadinia rotundifolia "Noble" and Vitis vinifera "Cabernet Sauvignon" were extracted and fractionated, and then they were analyzed with LC-MS and the inhibitory effects on breast cancer cells were compared. The inhibition on MDA-MB-231 cells of fractions from "Noble" was further evaluated. The results showed that polyphenols from 2 grape pomaces could be separated into 3 fractions, and ellagic acid and/or ellagitannins were only detected in fractions from "Noble" pomace. All 3 fractions from "Noble" pomace inhibited MDA-MB-231 better than MCF-7. But fraction 2 from "Cabernet Sauvignon" inhibited MCF-7 better while fraction 1 and fraction 3 inhibited both 2 cells similarly. Moreover, the fractions from "Noble" pomace rather than "Cabernet Sauvignon" can inhibit MDA-MB-231 better. Finally, fractions from "Noble" pomace can induce S-phase arrest and apoptosis on MDA-MB-231. These findings suggested the extracts from grape pomace especially those from "Noble", are potential to be utilized as health beneficial products or even anti-breast cancer agents.

分类号: TS2

  • 相关文献

[1]AKT signalling and mitochondrial pathways are involved in mushroom polysaccharide-induced apoptosis and G(1) or S phase arrest in human hepatoma cells. OuYang, Fengju,Wang, Guibin,Zhang, Yuanyuan,Zhao, Min,Guo, Wei,Xiang, Wenhua. 2013

[2]Polysaccharides from Phellinus linteus inhibit cell growth and invasion and induce apoptosis in HepG2 human hepatocellular carcinoma cells. Wang, Guibin,Dong, Lulu,Zhang, Yuanyuan,Zhao, Min,Ji, Yuanyuan,Xiang, Wenhua.

[3]Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis. Yang, Yan,Wu, Di,Zan, Xinyi,Cui, Fengjie,Li, Yunhong,Sun, Wenjing,Zan, Xinyi,Ping, Lifeng.

[4]Histone deacetylase inhibitor stimulates E2 and P4 secretion in sika deer ovarian granulosa cells at a moderate dose. Xing, Mingjie,Chen, Xiumin,Li, Xiaoxia,Wang, Xiaoxu,Cao, Xinyan,Cui, Xuezhe,Chang, Tong,Xu, Baozeng,Wei, Haijun,Yang, Yifeng,Xue, Hailong,Wang, Shiyong,Diao, Yunfei,Zhao, Weigang,Zhao, Meng. 2018

[5]Cell cycle arrest and apoptosis induced by aspidin PB through the p53/p21 and mitochondria-dependent pathways in human osteosarcoma cells. Jiang, Chaoyin,Wang, Ting,Chai, Yimin,Wan, Daqian,Hua, Xin. 2015

[6]The citrus flavonoid nobiletin inhibits proliferation and induces apoptosis in human pancreatic cancer cells in vitro. Zhang, Yu,Li, Hongjun,He, Zhifei,Zhang, Yu,Dou, Huating,Wu, Houjiu. 2014

[7]Candidacidal mechanism of the arenicin-3-derived peptide NZ17074 from Arenicola marina. Wang, Xiaojie,Wang, Xiumin,Teng, Da,Zhang, Yong,Mao, Ruoyu,Xi, Di,Wang, Jianhua,Wang, Xiaojie,Wang, Xiumin,Teng, Da,Zhang, Yong,Mao, Ruoyu,Xi, Di,Wang, Jianhua.

[8]In vitro and in vivo antioxidant activities of three major polyphenolic compounds in pomegranate peel: Ellagic acid, punicalin, and punicalagin. Sun Yu-qing,Xu Zi-wei,Wang Tian,Tao Xin,Men Xiao-ming,Xu Zi-wei. 2017

[9]Hydrogen Peroxide-Mediated Growth of the Root System Occurs via Auxin Signaling Modification and Variations in the Expression of Cell-Cycle Genes in Rice Seedlings Exposed to Cadmium Stress. Zhao, Feng-Yun,Han, Ming-Ming,Wang, Kai,Zhang, Cheng-Ren,Liu, Tao,Liu, Wen,Zhang, Shi-Yong. 2012

[10]Molecular cloning, sequence analysis, and function of the intestinal epithelial stem cell marker Bmi1 in pig intestinal epithelial cells. Li, C. -M.,Yan, H. -C.,Fu, H. -L.,Xu, G. -F.,Wang, X. -Q.. 2014

[11]The miR-302/367 cluster: a comprehensive update on its evolution and functions. Gao, Zeqian,Zhu, Xueliang,Dou, Yongxi. 2015

[12]Cucumber (Cucumis sativus L.) seed performance as influenced by ovary and ovule position. Jing, HC,Bergervoet, JHW,Jalink, H,Klooster, M,Du, SL,Bino, RJ,Hilhorst, HWM,Groot, SPC. 2000

[13]Effect of acute heat stress on calcium concentration, proliferation, cell cycle, and interleukin-2 production in splenic lymphocytes from broiler chickens. Han, A. Y.,Zhang, M. H.,Zheng, S. S.,Zhao, C. F.,Feng, J. H.,Cheng, C.,Han, A. Y.,Zuo, X. L.. 2010

[14]Molecular cloning and functional characterization of cyclin E and CDK2 from Penaeus monodon. Zhao, C.,Fu, M. J.,Qiu, L. H.,Zhao, C.,Fu, M. J.,Qiu, L. H.,Qiu, L. H.. 2016

[15]Overexpression of a Hevea brasiliensis ErbB-3 Binding protein 1 Gene Increases Drought Tolerance and Organ Size in Arabidopsis. Cheng, Han,Chen, Xiang,Zhu, Jianshun,Huang, Huasun. 2016

[16]Chicken CCDC152 shares an NFYB-regulated bidirectional promoter with a growth hormone receptor antisense transcript and inhibits cells proliferation and migration. Lin, Shudai,Luo, Wei,Jiang, Mingya,Luo, Wen,Abdalla, Bahareldin Ali,Nie, Qinghua,Zhang, Xiquan,Lin, Shudai,Luo, Wei,Jiang, Mingya,Luo, Wen,Abdalla, Bahareldin Ali,Nie, Qinghua,Zhang, Xiquan,Zhang, Li. 2017

[17]The anaphase-promoting complex initiates zygote division in Arabidopsis through degradation of cyclin B1. Guo, Lei,Jiang, Li,Zhang, Ying,Lu, Xiu-Li,Liu, Chun-Ming,Guo, Lei,Xie, Qi,Weijers, Dolf,Jiang, Li.

[18]Loss of Function of the Cytochrome P450 Gene CYP78B5 Causes Giant Embryos in Rice. Chen, Yilin,Liu, Linglong,Shen, Yingyue,Liu, Shijia,Huang, Jiexue,Long, Qizhang,Wu, Wei,Yang, Chunyan,Chen, Hong,Jiang, Ling,Wan, Jianmin,Guo, Xiuping,Cheng, Zhijun,Wan, Jianmin.

[19]Identification of the proteome complement of high royal jelly producing bees (Apis mellifera) during worker larval development. Zhang, Zhaohui,Pan, Yinghong,Li, Jianke,Li, Huawei,Li, Huawei.

[20]Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression. Wu, Xian,Song, Mingyue,Gao, Zili,Sun, Yue,Wang, Minqi,Li, Fang,Zheng, Jinkai,Xiao, Hang,Sun, Yue,Zheng, Jinkai.

作者其他论文 更多>>