Four new bi-2-(2-phenylethyl)chromone derivatives of agarwood from Aquilaria crassna

文献类型： 外文期刊

第一作者： Yang, Yang

作者： Yang, Yang;Chen, Zhi-Bao;Mei, Wen-Li;Kong, Fan-Dong;Chen, Hui-Qin;Li, Wei;Dai, Hao-Fu

作者机构：

关键词： Aquilaria crassna;Agarwood;Bi-2-(2-phenylethyl)chromone;Biological activity

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Four new bi-2-(2-phenylethyl)chromone derivatives, crassins A-D (1-4), were isolated from the EtOAc extract of agarwood originating from Aquilaria crassna. The structures including the absolute configurations of compounds were unambiguously elucidated by extensive spectroscopic methods (1D and 2D NMR, UV, ECD, IR, MS), and by comparison with the literature. The isolated compounds were tested for their acetylcholinesterase (AChE) and alpha-glucosidase inhibitory activities, as well as cytotoxic activities. All the compounds showed weak inhibitory activity against AChE, while compounds 3 and 4 also displayed weak cytotoxicity against human myeloid leukemia cell line (K562). (C) 2017 Published by Elsevier B.V.

分类号： S759.82

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