Antioxidant and anti-inflammatory effects of Chinese propolis during palmitic acid-induced lipotoxicity in cultured hepatocytes

文献类型： 外文期刊

第一作者： Jin, Xiao-Lu

作者： Jin, Xiao-Lu;Wang, Kai;Li, Qiang-Qiang;Tian, Wen-Li;Xue, Xiao-Feng;Wu, Li-Ming;Jin, Xiao-Lu;Hu, Fu-Liang

作者机构：

关键词： Propolis;Polyphenols;Lipoapoptosis;Hepatocytes;NAFLD

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Overload of hepatic palmitate, like palmitic acid (PA), is known as the key trigger for non-alcoholic fatty liver disease. Here, we investigated whether Chinese propolis (CP) would mitigate PA-induced lipotoxicity in hepatocytes. Total of 20 phenolic compounds were analysed in CP using HPLC-DAD/Q-TOF-MS. PA has significant cytotoxic effects on HepG2 and L02 hepatocytes, by decreasing cell viability and inducing LDH releases, which was rescued by CP pre-treatment. Lipoapoptosis was also found in HepG2 hepatocytes treated with PA and CP helped restore the energy provision and prevented cell apoptosis. After PA challenges, antioxidant effects of CP were also observed by boosting the HepG2 cellular total antioxidant potentials, increasing superoxide dismutase level and up-regulating antioxidant/detoxicant gene expressions (GSTA1, TXNRDI, NQO-1, HO-1 and Nrf2). Notably, gene expressions of inflammatory cytokine, TNF-alpha and IL-8, were decreased by CP. Therefore, CP protects hepatocytes against PA induced lipotoxicity by lowering biomarkers of apoptosis, oxidative stress and inflammation. (C) 2017 Elsevier Ltd. All rights reserved.

分类号： TS2

  • 相关文献

[1]Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract against carbon tetrachloride (CCl4)-induced hepatocyte damage in common carp (Cyprinus carpio). Yin, Guojun,Lu, Chengping,Yin, Guojun,Cao, Liping,Xu, Pao,Jeney, Galina,Nakao, Miki. 2011

[2]Leptin stimulates hepatic activation of thyroid hormones and promotes early posthatch growth in the chicken. Li, Rongjie,Hu, Yan,Ni, Yingdong,Zhao, Ruqian,Li, Rongjie,Xia, Dong,Hu, Yan,Grossmann, Roland.

[3]Biological characterization of liver fatty acid binding gene from miniature pig liver cDNA library. Gao, Y. H.,Wang, K. F.,Zhang, S.,Fan, Y. N.,Guan, W. J.,Ma, Y. H.,Gao, Y. H.,Wang, K. F.,Zhang, S.,Fan, Y. N.. 2015

[4]Purification, characterisation and protective effects of polysaccharides from alfalfa on hepatocytes. Wang, Shaopu,Dong, Xiaofang,Cui, Yaoming,Tong, Jianming,Ma, Hao.

[5]Dietary Propolis Ameliorates Dextran Sulfate Sodium-Induced Colitis and Modulates the Gut Microbiota in Rats Fed aWestern Diet. Wang, Kai,Tian, Wenli,Wu, Liming,Wang, Kai,You, Mengmeng,Hu, Fuliang,Wang, Kai,Topping, David L.,Conlon, Michael A.,Jin, Xiaolu,Le Leu, Richard K.. 2017

[6]Determination of organochlorine pesticides in propolis by gas chromatography-electron capture detection using double column series solid-phase extraction. Chen, Fang,Chen, Lanzhen,Zhou, Jinhui,Xue, Xiaofeng,Zhao, Jing,Wang, Qiang.

[7]A Feasibility Study on the Discrimination of the Propolis Varieties Based on Near Infrared Spectroscopy. Yang Juan,Chen Lan-zhen,Xue Xiao-feng,Wu Li-ming,Li Yi,Wu Zhao-bin,Yang Juan,Chen Lan-zhen,Xue Xiao-feng,Wu Li-ming,Li Yi,Wu Zhao-bin,Zhang Yan-nan,Zhao Jing. 2016

[8]Multiresidue Determination Of Tetracycline Antibiotics In Propolis By Using Hplc-uv Detection With Ultrasonic-assisted Extraction And Two-step Solid Phase Extraction. Zhou, Jinhui,Xue, Xiaofeng,Li, Yi,Zhang, Jinzhen,Chen, Fang,Wu, Liming,Chen, Lanzhen,Zhao, Jing.

[9]Study on the immune enhancement of different immunoadjuvants used in the pentavalent vaccine for turbots. Zhang Zheng,Wang Yingeng,Wang Qingyin,Deng Nannan,Liao Meijie,Li Bin,Wang Lan,Zhang Zheng,Qu Jiangbo. 2012

[10]Dichloromethane extracts of propolis protect cell from oxygen-glucose deprivation-induced oxidative stress via reducing apoptosis. Sun, Li-Ping,Xu, Xiang,Wang, Xin,Hwang, Hau-Hsuan,Su, Kang-Yi,Chen, Yi-Lin S.. 2016

[11]Mechanisms underlying the wound healing potential of propolis based on its in vitroi antioxidant activity. Cao, Xue-Ping,Chen, Yi-Fan,Hu, Fu-Liang,Zhang, Jiang-Lin,You, Meng-Meng,Wang, Kai. 2017

[12]Comparison of Phenolic Content and Antioxidant Capacity of Red and Yellow Onions. Cheng, Anwei,Chen, Xiangyan,Jin, Qiong,Wang, Wenliang,Shi, John,Liu, Yaobo,Shi, John. 2013

[13]Antioxidant activity of polyphenol and anthocyanin extracts from fruits of Kadsura coccinea (Lem.) AC Smith. Yao, Jinyan,Huang, Shaoxi,Sun, Jian,Wang, Jubing,Garcia-Garcia, Elena,Garcia-Garcia, Elena. 2009

[14]Variation and correlation analysis of polyphenolic compounds in Malus germplasm. Wang, Dajiang,Wang, Kun,Li, Jing,Gao, Yuan,Zhao, Jirong,Liu, Lijun,Gong, Xin,Dong, Xingguang. 2018

[15]ANTI-FATIGUE EFFECTS OF POLYPHENOLS EXTRACTED FROM ARECA CATECHU L. HUSK AND DETERMINATION OF THE MAIN COMPONENTS BY HIGH PERFORMANCE CAPILLARY ELECTROPHORESIS. Tang, Minmin,Chen, Hua,Zhao, Songlin,Wang, Hui,Qi, Jing. 2016

[16]Chemical composition, nutritional value, and antioxidant activities of eight mulberry cultivars from China. Liang, Linghong,Wu, Xiangyang,Zhu, Maomao,Li, Fang,Zou, Ye,Yang, Liuqing,Zhao, Weiguo. 2012

[17]High temperature and UV-C treatments affect stilbenoid accumulation and related gene expression levels in Gnetum parvifolium. Deng, Nan,Liu, Caixia,Chang, Ermei,Ji, Jing,Yao, Xiamei,Yue, Jianyun,Jiang, Zeping,Shi, Shengqing,Bartish, Igor V.,Chen, Lanzhen,Chen, Lanzhen. 2017

[18]Sweet potato (Ipomoea batatas L.) leaves as nutritional and functional foods. Sun, Hongnan,Mu, Taihua,Xi, Lisha,Zhang, Miao,Chen, Jingwang.

[19]Extraction optimization of polyphenols, antioxidant and xanthine oxidase inhibitory activities from Prunus salicina Lindl.. Li, Yibin,Lai, Pufu,Chen, Junchen,Shen, Hengsheng,Tang, Baosha,Wu, Li,Weng, Minjie. 2016

[20]The major factors influencing the formation of sediments in reconstituted green tea infusion. Xu, Yong-Quan,Jiang, Yong-Wen,Yuan, Hai-Bo,Yin, Jun-Feng,Xu, Yong-Quan,Hu, Xiong-Fei,Du, Qi-Zhen,Tang, Ping.

作者其他论文 更多>>

微信小程序