Phenolic acids alleviate high-fat and high-fructose diet-induced metabolic disorders in rats

文献类型: 外文期刊

第一作者: Guo, Xiaoxuan

作者: Guo, Xiaoxuan;Ji, Baoping;Zhou, Feng;Wang, Ou;Wang, Yong;Wang, Kai

作者机构:

关键词: high-fructose and high-fat diet;metabolic syndrome;phenolic acids

期刊名称:JOURNAL OF FOOD BIOCHEMISTRY ( 影响因子:2.72; 五年影响因子:2.543 )

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收录情况: SCI

摘要: Phenolic acids are naturally occurring compounds with meritorious physiological activities. The purpose of this study was to compare the ameliorative effects of six common phenolic acids on diet-induced metabolic syndrome (MS) in rats. SD rats were fed with high-fat and high-fructose diet supplemented with equimolar concentration of individual phenolic acids for 13 weeks. Results showed that different phenolic acids ameliorated MS through different ways. Compared with other phenolic acids, caffeic acid exerted more comprehensive effect in alleviating MS, with significant effects in attenuating hyperlipidemia, elevating glucose tolerance, improving antioxidant status, and normalizing hepatic functions. Ellagic acid exhibited good performance in hypolipidemia, anti-inflammation, and reducing visceral fat. Gallic acid and -coumaric acid showed marked effects in regulating liver steatosis, while chlorogenic acid exhibited potential hepatic protective and anti-inflammatory abilities. These results will benefit the application of these phenolic acids in the development of functional food for MS population.

分类号: TS2

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