Antidiabetic lanostane triterpenoids from the fruiting bodies of Ganoderma weberianum

文献类型： 外文期刊

第一作者： Yang, Li

作者： Yang, Li;Kong, De-Xian;Ma, Qing-Yun;Xie, Qing-Yi;Guo, Jiao-Cen;Ma, Hai-Xia;Dai, Hao-Fu;Zhao, You-Xing;Kong, De-Xian;Hua, Yan;Xiao, Na;Deng, Chun Ying

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关键词： Ganoderma weberianum; Lanostane triterpenoids; alpha-glucosidase inhibitory activity; Molecular docking

期刊名称：BIOORGANIC CHEMISTRY （ 影响因子：5.307； 五年影响因子：5.321 ）

ISSN： 0045-2068

年卷期： 2022 年 127 卷

页码：

收录情况： SCI

摘要： Eight previously undescribed lanostane triterpenoids, ganodeweberiols A similar to H (1-8), together with eighteen known compounds (9-26), were isolated from the fruiting bodies of Ganoderma weberianum. The structures and absolute configurations of the new compounds were determined by extensive spectroscopic analysis, as well as NMR chemical shifts and electronic circular dichroism (ECD) calculations. Compounds 2, 7, 12, and 14 showed significant alpha-glucosidase inhibitory activity with IC50 values ranging from 35.3 mu M similar to 223.4 mu M compared to the positive control acarbose (IC50, 304.6 mu M). Kinetic study indicated that the most potent compound 12 was a mixed type inhibitor for alpha-glucosidase. Molecular docking simulation revealed the interactions of 12 with alpha-glucosidase. Additionally, Compounds 3 and 6 inhibited glucagon-induced hepatic glucose production in HepG2 cells with EC50 values of 42.0 and 85.9 mu M, respectively. Further study revealed that compounds 3 and 6 inhibited hepatic glucose production by suppression glucagon-induced cAMP accumulation. Moreover, compounds 3 and 26 were active against HeLa cell line with IC50 values of 17.0 and 6.8 mu M, respectively.

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