Antioxidant and Cytotoxic Activities of Ethanolic Extracts and Isolated Fractions of Species of the Genus Phellinus Quel. (Aphyllophoromycetideae)

文献类型： 外文期刊

第一作者： Yang, Yan

作者： Yang, Yan;Hu, Jinxia;Liu, Yanfang;Feng, Na;Chen, Hui;Tang, Qingjiu;Zhang, Jingsong;Ye, LinBin

作者机构：

关键词： medicinal mushrooms;species of the genus Phellinus;ethanolic extracts;antioxidant;antitumor activity

期刊名称：INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS （ 影响因子：1.921； 五年影响因子：1.879 ）

ISSN： 1521-9437

年卷期： 2011 年 13 卷 2 期

页码：

收录情况： SCI

摘要： Ethanolic extracts of fruit bodies of 5 species (8 strains) of the genus Phellinus, and isolated fractions derived from 1 of these extracts (Ph. baumii PB-10), were evaluated for antioxidant activity, inhibitory effects on the growth of human tumor cells, and the capacity to protect PC12 cells against H(2)O(2)-induced oxidative damage. Extracts of all 8 strains of Phellinus spp. exhibited antioxidant activity and protected PC12 cells against oxidative damage at different magnitudes of potency. The strongest antioxidant activity was exhibited by extracts of Ph. baumii PB-10, with recorded IC(50) values for superoxide radical and hydrogen peroxide scavenging activity of 3.76 mu g/mL and 4.24 mu g/mL, respectively. Radical-scavenging activity and protection levels against H(2)O(2)-induced damage to PC12 cells were highly correlated with the flavonoid content of the extracts and isolated fractions. All the extracts inhibited L1210, SW620, and MCF-7 tumor cell proliferation at 200 mu g/mL concentrations, but inhibition was not correlated with the flavone content of the test samples and was clearly dependent upon the presence of other, as yet, unidentified components. Our data indicate that fruit bodies of species of the genus Phellinus represent a potentially valuable source of natural antioxidants of relevance to both the health and food industries.

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