A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

文献类型： 外文期刊

第一作者： Jing, Maofeng

作者： Jing, Maofeng;Guo, Baodian;Li, Haiyang;Yang, Bo;Wang, Haonan;Kong, Guanghui;Zhao, Yao;Xu, Huawei;Wang, Yan;Ye, Wenwu;Dong, Suomeng;Wang, Yuanchao;Jing, Maofeng;Guo, Baodian;Li, Haiyang;Yang, Bo;Wang, Haonan;Kong, Guanghui;Zhao, Yao;Xu, Huawei;Wang, Yan;Ye, Wenwu;Dong, Suomeng;Wang, Yuanchao;Qiao, Yongli;Tyler, Brett M.;Tyler, Brett M.;Ma, Wenbo;Ma, Wenbo

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：14.919； 五年影响因子：15.805 ）

ISSN： 2041-1723

年卷期： 2016 年 7 卷

页码：

收录情况： SCI

摘要： Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.

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