The miR-302/367 cluster: a comprehensive update on its evolution and functions

文献类型: 外文期刊

第一作者: Gao, Zeqian

作者: Gao, Zeqian;Zhu, Xueliang;Dou, Yongxi

作者机构:

关键词: miR-302/367 cluster;evolution;transcriptional regulation;cell cycle;cellular signalling;epigenetic regulation

期刊名称:OPEN BIOLOGY ( 影响因子:6.411; 五年影响因子:5.898 )

ISSN: 2046-2441

年卷期: 2015 年 5 卷 12 期

页码:

收录情况: SCI

摘要: microRNAs are a subclass of small non-coding RNAs that fine-tune the regulation of gene expression at the post-transcriptional level. The miR-302/367 cluster, generally consisting of five members, miR-367, miR-302d, miR-302a, miR-302c and miR-302b, is ubiquitously distributed in vertebrates and occupies an intragenic cluster located in the gene La-related protein 7 (LARP7). The cluster was demonstrated to play an important role in diverse biological processes, such as the pluripotency of human embryonic stem cells (hESCs), self-renewal and reprogramming. This paper provides an overviewof the mir-302/367 cluster, discusses our current understanding of the cluster's evolutionary history and transcriptional regulation and reviews the literature surrounding the cluster's roles in cell cycle regulation, epigenetic regulation and different cellular signalling pathways.

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