Antiviral activity of doxycycline against vesicular stomatitis virus in vitro

文献类型: 外文期刊

第一作者: Wu, Zhuan-chang

作者: Wu, Zhuan-chang;Wei, Jian-chao;Li, Bei-bei;Shao, Dong-hua;Li, Yu-ming;Liu, Ke;Shi, Yuan-yuan;Qiu, Ya-feng;Ma, Zhi-yong;Wang, Xin;Zhou, Bin

作者机构:

关键词: doxycycline;vesicular stomatitis virus;antiviral activity

期刊名称:FEMS MICROBIOLOGY LETTERS ( 影响因子:2.742; 五年影响因子:2.856 )

ISSN: 0378-1097

年卷期: 2015 年 362 卷 22 期

页码:

收录情况: SCI

摘要: Doxycycline (Dox) is a tetracycline derivative with broad-spectrum antimicrobial activities that is used as an effector substance in inducible gene-expression systems. We investigated the antiviral activity of Dox against vesicular stomatitis virus (VSV) infection in cultured H1299 cells. Dox at concentrations of 1.0-2.0 mu g ml(-1) significantly inhibited VSV replication and the VSV-induced cytopathic effect in dose-dependent manners, suggesting that Dox may have broader activity in inhibiting viral replication, in addition to its well-defined bacteriostatic activity. Dox exerted its antiviral effect at the early-mid stage of VSV infection, suggesting that it did not interfere with VSV infectivity, adsorption, or entry into target cells. These results indicate that Dox can inhibit VSV infection and may therefore have potential applications for the treatment of viral infections.

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