Two new indole alkaloids isolated from a mangrove-derived fungus Colletotrichum sp. HD-1

文献类型: 外文期刊

第一作者: He, Dan

作者: He, Dan;Zhu, Hong-Juan;Wu, You-Gen;Yang, Dong-Mei;He, Dan;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You -Xing;Yang, Dong-Mei;Yang, Dong-Mei;Zhao, You -Xing

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关键词: Acrostichum aureum; Endophytic fungi; Colletotrichum sp; Indole alkaloids; Colletotryptin

期刊名称:PHYTOCHEMISTRY LETTERS ( 影响因子:1.7; 五年影响因子:1.8 )

ISSN: 1874-3900

年卷期: 2023 年 54 卷

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收录情况: SCI

摘要: Two new indole alkaloids, colletotryptins G (1) and H (2), along with four known alkaloids (3-6), were isolated from an endophytic fungus Colletotrichum sp. HD-1 (Melanconiaceae) derived from the mangrove plant Acros-tichum aureum (Pteridaceae). The structures of new compounds were elucidated by comprehensive analysis of their UV, HRESIMS, and NMR data. All the isolates were evaluated for their alpha-glucosidase and acetylcholines-terase inhibitory, antibacterial, and antifungal activities. Only compound 2 showed stronger inhibitory activity against alpha-glucosidase with IC50 value of 133.4 mu M than that of the positive control acarbose (319.8 mu M).

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