Role of MicroRNAs in Hepatocellular Carcinoma

文献类型： 外文期刊

第一作者： Zhu, Zixiang

作者： Zhu, Zixiang;Zhang, Xiangle;Zheng, Haixue;Wang, Guoqing

作者机构：

关键词： Hepatocellular Carcinoma;MicroRNAs;Regulation;Therapeutic Targets

期刊名称：HEPATITIS MONTHLY （ 影响因子：0.66； 五年影响因子：1.409 ）

ISSN： 1735-143X

年卷期： 2014 年 14 卷 8 期

页码：

收录情况： SCI

摘要： Context: MicroRNAs (miRNAs) are small, noncoding RNAs that play an important role in posttranscriptionalgene regulation and function as negative gene regulators. They are an abundant class of RNA, each of which can control hundreds of gene targets and regulate diverse biological processes such as hematopoiesis, organogenesis, apoptosis and cell proliferation. Aberrant miRNA expression contributes to tumorigenesis and cancer progression. Evidence Acquisition: In this study we provided a summarized review of the most important new data available on hepatocellular carcinoma (HCC)-associated miRNAs. The data were collected through searching the related keywords and were categorized and summarized in different sections. Results: Researchers have reported that miRNAs can repress the expression of important cancer-related genes and might be helpful in the diagnosis and treatment of cancer. During the past two decades, numerous studies have shown that miRNAs play an essential role in inhibiting HCC via several different pathways. Deregulated miRNAs may contribute to carcinogenesis, indicating that miRNAs can act as tumor suppressors and oncogenes. Conclusions: In this mini review, we highlight current findings and discuss recent work to determine the contribution of miRNA expression to the maintenance and growth of HCC, thereby providing a significant source of hope that miRNAs could serve as therapeutic targets.

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