Design, Synthesis and Bioactivity of N-Glycosyl-N '-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives

文献类型： 外文期刊

第一作者： Cui, Zining

作者： Cui, Zining;Nishida, Yoshihiro;Su, Hang;Jiang, Jiazhen;Yang, Xinling;Cui, Zining

作者机构：

关键词： glycosylhydrazide;synthesis;tautomer;antifungal activity;antitumor activity

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1422-0067

年卷期： 2014 年 15 卷 4 期

页码：

收录情况： SCI

摘要： Condensation products of 5-substituted phenyl-2-furoyl hydrazide with different monosaccharides D-glucose, D-galactose, D-mannose, D-fucose and D-arabinose were prepared. The anomerization and cyclic-acyclic isomers were investigated by H-1 NMR spectroscopy. The results showed that, except for the D-glucose derivatives, which were in the presence of beta-anomeric forms, all derivatives were in an acyclic Schiff base form. Their antifungal and antitumor activities were studied. The bioassay results indicated that some title compounds showed superior effects over the commercial positive controls.

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