文献类型: 外文期刊
第一作者: Liu Kechang
作者: Liu Kechang;Wang Yi;Zhang Hao;Liu Ruiquan;Li Qibo;Liu Shangzhong;Wang Qingmin;Li Yongqiang;Rui Changhui
作者机构:
关键词: 2,3-disubstituted quinazolin-4(3H)-ones;synthesis;bioactivities;crystal structure
期刊名称:CHINESE JOURNAL OF ORGANIC CHEMISTRY ( 影响因子:1.652; 五年影响因子:1.2 )
ISSN: 0253-2786
年卷期: 2014 年 34 卷 3 期
页码:
收录情况: SCI
摘要: In this research, a series of new 2,3-disubstituted quinazolin-4(3H)-ones were designed and synthesized. The influence of common drying agents on the formation of 2,3-disubstituted quinazolin-4(3H)-ones was investigated and firstly reported. It is found that the anhydrous magnesium sulfate can increase the yield of 2,3-disubstituted quinazolin-4(3H)-ones significantly. The structures of new compounds were all confirmed via H-1 NMR, C-13 NMR and HRMS. At the same time, the crystal structure of 3-(benzylamino)-6-chloro-8-methyl-2-neopentyl-quinazolin-4(3H)-one was firstly reported. The results of bioactivity assay showed that some of these new compounds have some control effects on wheat powdery mildew (Blumeria graminis) in vivo at a concentration of 200 mg/L.
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