Safety evaluation of phytosterols in laying hens: Effects on laying performance, clinical blood parameters, and organ development

文献类型： 外文期刊

第一作者： Shi, S. R.

作者： Shi, S. R.;Shen, Y. R.;Chang, L. L.;Bo, Z.;Tong, H. B.;Zou, J. M.;Zhou, C. J.;Wang, Z. Y.

作者机构：

关键词： phytosterol;laying hen;safety evaluation;clinical blood parameter;organ development

期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）

ISSN： 0032-5791

年卷期： 2014 年 93 卷 3 期

页码：

收录情况： SCI

摘要： Phytosterols are intended for use as a novel food ingredient with plasma cholesterol-lowering activity. Although phytosterols are naturally present in the normal diet, daily consumption is insufficient to ensure plasma cholesterol-lowering levels. Therefore, phytosterols may be added to the diets to achieve the desired cholesterol-lowering activity. A subchronic laying hen safety study was conducted to examine if high-dose phytosterols could affect the safety of hens. Three hundred sixty 21-wk-old Hy-Line Brown laying hens were randomly assigned to 5 groups with 6 replicates of 12 birds each; after 3 wk, birds were fed diets supplemented with 0, 20, 80, 400, and 800 mg/kg of phytosterols for 12 wk. Throughout the study, clinical observations and laying performance were measured. At the end of the study, birds were subjected to a full postmortem examination: blood samples were taken for clinical pathology, selected organs were weighed, and specified tissues were taken for subsequent histological examination. No treatment-related changes that were considered to be of toxicological significance were observed. Therefore, a nominal phytosterol concentration of 800 mg/kg was considered to be the no-observed-adverse-effect level.

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